COGNIBIOTICS: BRAIN FOG SUPPLEMENT
Mental Fatigue Getting The Best Of You?
Brain fog and lack of mental clarity can be major obstacles and sources of frustration in our journey to optimal health and peak performance. Whether we want to give our best at work, or simply enjoy the fullness of life, being unable to focus on our goals or the tasks at hand interferes with our ability to be present and achieve success.
Though many of us recognize when our bodies need a little more attention, we're not so quick to nurture our cognitive health. Mental decline and weakened cognitive performance might be common, but they don't have to be your normal.
- Boost your brain health, mental clarity, learning, memory, and focus by improving your gut bacteria
- Relieve brain fog and procrastination
- Promote relaxation and a balanced stress response
- Enhance cognitive function, mood and stress resilience by improving your gut flora
- Balance your neurotransmitters, including acetylcholine, serotonin, GABA, and dopamine in the brain
- Protect your brain against oxidative stress
- Improve blood circulation to the brain
- Support digestive health and bowel regularity
HOW TO GET RID OF BRAIN FOG?
Brain fog refers to confusion, forgetfulness, and inability to focus or think clearly. It is not a formal diagnosis, but a symptom that many people struggle with. Though it's become common, it is not "normal" or "healthy." Brain fog could be a symptom of mental health issues or the beginning stages of cognitive decline, so it is important to identify its underlying root causes and address them.
High levels of oxidative stress in the brain jams the brain mitochondria, causing your neurons to be sluggish. Lifestyle factors that elevate brain oxidative stress include:
- Unhealthy and inflammatory diets
- Imbalanced gut microbiome
- Poor sleep or an unhealthy circadian rhythm
- Stressful or traumatic life events Sedentary lifestyle
- Sedentary lifestyle
- Poor blood sugar control
- Nutrient deficiencies
- To get rid of brain fog, these factors need to be identified and addressed. Cognibiotics can help with brain fog by improving the gut microbiome, stress resilience, and gut health.
More Than A Probiotic...
CogniBiotics is the only probiotic-nootropic blend on the market that improves the entire gut-brain-microbiota axis. In addition to containing some of the best probiotic strains for cognitive performance, it also contains:
- The Chaihu Shugan San herb blend, used for over 2,200 years in traditional Chinese medicine to enhance brain health, focus, and happiness levels through the gut microbiome.
- The An Shen Bu Xin San herbal blend, an equally ancient Chinese formula traditionally used to calm the spirit, known for its cognitive performance-enhancing properties.
- Antioxidants suitable for the brain in order to protect it from oxidative stress and “mental aging”.
- A prebiotic complex that secures the good bacteria arrives healthy to your gut and rebalances your body’s microbiome.
This state of the art formulation is designed to:
- Improve mood and promote a balanced stress response
- Increase mental clarity, sharpness, enhanced memory and beat brain fog
- Promote a better microbiome balance in the gut, which boosts a healthy gut-brain connection
What are nootropics, and how can they help your brain function?
Nootropics are substances known to improve cognitive function, including memory, creativity, sharpness and motivation. They're nutrients for the brain.
But unlike many of the nutrients we get through a healthy diet, getting nootropics through food sources alone can be close to impossible. That’s why we made it our mission to combine the best nootropics available into a single brain health supplement, where all the ingredients work together synergistically. Not all brain supplements are formulated the same, and we created the best supplement to keep your mind sharp and boost your brainpower.
THE UNTOLD TRUTH ABOUT THE SECOND BRAIN
We all know that probiotics are good for the body because they enhance digestion but… how does that impact the brain?
The brain and the gut are intricately connected through what’s known as Gut-Brain-Microbiome Axis [1]. Just like the brain, the gut contains over 30 different types of neurotransmitters.
About 90% of serotonin, also known as “the happiness hormone,” is produced in the gut. [2] GABA, dopamine, acetylcholine, and melatonin, among other key neurotransmitters, are also produced there. It’s no surprise the gut is often called, "THE SECOND BRAIN".
Good bacteria in the gut are responsible for generating these neurochemicals.[3]
That’s why probiotics are the key to a balanced microbiome that is capable of enhancing mental health…
But not all probiotic brain supplements are the same. For Cognibiotics, we carefully selected the 10 strains that are scientifically proven to be the most efficient at regulating the brain-gut axis. We then made sure they're capable of surviving the various changes in pH throughout the digestive tract.z
Beating Brain Fog By Optimizing The Gut-Brain-Microbiome Axis
Brain fog, memory issues and difficulty concentrating are easily mistaken with being absent-minded or simply lazy. In reality, they're more often signs of improper communication between brain cells. Chemicals known as neurotransmitters are responsible for this communication, and the bacteria balance in our gut plays a key role in their production [4].
Research has shown that improving the microbiome composition can be beneficial, even for people with neurological disorders [5]. But please note, Cognibiotics is not a substitute for medical treatment. Consult a physician before beginning any new supplement, diet, training program, or if you’re undergoing treatment of a medical condition.
Promotes Learning And Memory
Acetylcholine is an important neurotransmitter for learning and memory.
P. multiflorum, S. miltiorrhiza, and R. glutinosa in Cognibiotics increase acetylcholine levels [7].
Most brain supplements in the market contain ingredients that boost cognitive function, but these probiotics are like having a factory of positive neurochemicals in your own body.
Balance Your Stress Response
Studies show[8] the probiotics L. plantarum, L. helveticus, L. fermentum, L. rhamnosus, and B. infantis promote the balance of serotonin, dopamine and GABA in the brain.
Well-balanced neurotransmitters will help to boost and sustain your mood, improve cognitive function, and support you in having a healthy stress response.
Helps Your Brain “Stay In Shape”
The brain is a muscle. Like other muscles, it is strengthened through consistent use and proper nourishment.
The good bacteria [9] and herbs [10] in Cognibiotics work together to stimulate the production of proteins that help the brain grow, reorganize, and adapt. Increasing these proteins helps with learning, memory, and mood.
This is why Cognibiotics is one of the best brain health supplements for improving cognitive functions.
Helps Your Brain Stand The Test Of Time.
The herbal blends in Cognibiotics also help to protect neurons against oxidative stress.
Oxidative stress is an inevitable part of our daily routine. It comes from mental and emotional stress, environmental toxins, inflammation, unhealthy lifestyle, and more. We rarely consume enough antioxidants in our diets to withstand oxidative stress. This can contribute to brain cell damage, which may lead to brain fog, fatigue, and neurological aging.
Herbs in Cognibiotics contain antioxidants that can cross the blood-brain barrier and protect your brain from day-to-day oxidative stress [11].
Increases Blood Flow To The Brain
Your brain needs oxygen and vital nutrients to work well. Because it's located at the highest point in your body and connects to many tiny blood vessels, it's also the organ that's hardest to deliver blood to.
This reduced blood flow can translate to deprivation of proper oxygen and nutrients. This can cause fatigue, brain fog, poor memory, and low mood. This reduced blood flow can translate to deprivation of oxygen and nutrients. This can cause fatigue, brain fog, poor cognitive function, and low mood.
The Chaihu-Shugan San herb formula normalizes brain blood flow [12] in patients with depression.
Producing Beneficial Substances From Probiotic Metabolism
Among the benefits of probiotics is the generation of beneficial chemicals from their metabolism, “postbiotics”. One of the most well known is butyrate.
Low mood, brain fog, and fatigue[13] are caused by sluggish neurons that can’t produce enough energy (ATP). The small fatty acids like butyrate[14] can enter the brain, energize the sluggish neurons, and lower oxidative stress.
The small fatty acids also counteract chronic inflammation[15] and strengthen the gut and blood-brain barriers[16]. They also promote a healthy metabolism and blood sugar levels which are important for mental alertness.
TIRED OF FEELING TIRED?
Brain fog, low mood, and low performance could be standing between you and your goals!
STILL WONDERING IF COGNIBIOTICS COULD HELP YOU REACH YOUR POTENTIAL?
Here's everything you need to know before getting Cognibiotics
THE BENEFITS OF COGNIBIOTICS PROBIOTIC BACKED BY SCIENCE
- Martin CR, Osadchiy V, Kalani A, Mayer EA. The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol. 2018;6(2):133-148. https://doi.org/10.1016/j.jcmgh.2018.04.003
- De Vadder F, Grasset E, Mannerås Holm L, et al. Linking the gut Microbiota to a brain neurotransmitter. Proc Natl Acad Sci U S A. 2018;115(25):6458-6463.
- Jameson KG, Hsiao EY. The role of protein digestibility and antacids on food allergy outcomes. Trends Neurosci. 2018;41(7):413-414. https://doi.org/10.1016/j.tins.2018.04.001
- Morais, L. H., Schreiber, H. L., 4th, & Mazmanian, S. K. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021;19(4):241-255. https://doi.org/10.1038/s41579-020-00460-0
- Cryan JF, O'Riordan KJ, Cowan CSM, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877-2013. doi:10.1152/physrev.00018.2018
- Yu M, Jia HM, Zhang T, et al. Gut Microbiota is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San. Metabolites. 2020;10(2):63. Published 2020 Feb 10. doi:10.3390/metabo10020063
- Howes MR, Fang R, Houghton PJ. Effect of Chinese Herbal Medicine on Alzheimer's Disease. Int Rev Neurobiol. 2017;135:29-56. doi:10.1016/bs.irn.2017.02.003
- Wang H, Lee IS, Braun C, Enck P. Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review. J Neurogastroenterol Motil. 2016;22(4):589-605. doi:10.5056/jnm16018
- Ohland CL, Kish L, Bell H, et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Psychoneuroendocrinology. 2013;38(9):1738-1747. doi:10.1016/j.psyneuen.2013.02.00
- Feng DD, Tang T, Lin XP, et al. Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review. Neuropsychiatr Dis Treat. 2016;12:2387-2402. Published 2016 Sep 20. doi:10.2147/NDT.S114560 11
- Packer L. Oxidative stress, antioxidants, aging and disease. In: Cutler R.G., Packer L., Bertram J., Mori A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel; 1995:1-14. https://doi.org/10.1007/978-3-0348-7337-6_1 Molecular and Cell Biology Updates. Birkhäuser Basel; 1995:1-14. https://doi.org/10.1007/978-3-0348-7337-6_1
- Qiu J, Hu SY, Shi GQ, Wang SE. Changes in regional cerebral blood flow with Chaihu-Shugan-San in the treatment of major depression. Pharmacogn Mag. 2014;10(40):503-508. doi:10.4103/0973-1296.141775
- Schönfeld P, Wojtczak L. Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res. 2016;57(6):943-954. doi:10.1194/jlr.R067629
- Chambers ES, Preston T, Frost G, Morrison DJ. Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep. 2018;7(4):198-206. doi:10.1007/s13668-018-0248-8
- Braniste V, Al-Asmakh M, Kowal C, et al. The gut microbiota influences blood-brain barrier permeability in mice[published correction appears in Sci Transl Med. 2014 Dec 10;6(266):266er7. Guan, Ng Lai [corrected to Ng, Lai Guan]]. Sci Transl Med. 2014;6(263):263ra158. doi:10.1126/scitranslmed.3009759
- Puddu A, Sanguineti R, Montecucco F, Viviani GL. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm. 2014;2014:162021. doi:10.1155/2014/162021
- Miranda M, Morici JF, Zanoni MB, Bekinschtein P. Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Front Cell Neurosci. 2019;13:363. Published 2019 Aug 7. doi:10.3389/fncel.2019.00363
- Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci. 2001;933:222-234. doi:10.1111/j.1749-6632.2001.tb05827
- Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic Review of Gut Microbiota and Major Depression. Front Psychiatry. 2019;10:34. Published 2019 Feb 11. doi:10.3389/fpsyt.2019.00034
- Moser G, Fournier C, Peter J. Intestinal microbiome-gut-brain axis and irritable bowel syndrome. Intestinal Mikrobiom-Darm-Hirn-Achse und Reizdarmsyndrom. Wien Med Wochenschr. 2018;168(3-4):62-66. doi:10.1007/s10354-017-0592-0
- Kay I. Kay I. Is Your Mood Disorder a Symptom of Unstable Blood Sugar?. Available at: https://sph.umich.edu/pursuit/2019posts/mood-blood-sugar-kujawski.html. Published 2019. Accessed February 23, 2021.
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- Rao TS, Asha MR, Ramesh BN, Rao KS. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008;50(2):77-82. doi:10.4103/0019-5545.42391
- Rao V, Bertrand M, Rosenberg P, et al. Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2010;22(1):100-104. doi:10.1176/jnp.2010.22.1.100
- Karl JP, Hatch AM, Arcidiacono SM, et al. Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota. Front Microbiol. 2018;9:2013. Published 2018 Sep 11. doi:10.3389/fmicb.2018.02013
- Caspani G, Kennedy S, Foster JA, Swann J. Gut microbial metabolites in depression: understanding the biochemical mechanisms. Microb Cell. 2019;6(10):454-481. Published 2019 Sep 27. doi:10.15698/mic2019.10.693
- Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018;12:49. Published 2018 Feb 7. doi:10.3389/fnins.2018.00049
- Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050-16055. doi:10.1073/pnas.1102999108
- Fung TC. The microbiota-immune axis as a central mediator of gut-brain communication. Neurobiol Dis. 2020;136:104714. doi:10.1016/j.nbd.2019.104714
- Wang H, Lee IS, Braun C, Enck P. Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review. J Neurogastroenterol Motil. 2016;22(4):589-605. doi:10.5056/jnm16018
