MAGNESIUM BREAKTHROUGH ADVANCED 10

MAGNESIUM BREAKTHROUGH ADVANCED 10

MAGNESIUM BREAKTHROUGH ADVANCED 10

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MAGNESIUM BREAKTHROUGH ADVANCED 10

10 Bioavailable Forms · 550mg Elemental Magnesium ·
P5P + Ionic Trace Minerals

$200.00 $87.00

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60 Capsules
  • 10 bioavailable forms of magnesium for complete, whole-body support*
  • Supports relaxation & restorative sleep*
  • 550mg of elemental magnesium per serving
  • Promotes a healthy stress response*
  • Helps maintain healthy metabolic health*
  • Supports muscle function & recovery
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  • 10 bioavailable forms of magnesium for complete, whole-body support*
  • Supports relaxation & restorative sleep*
  • 550mg of elemental magnesium per serving
  • Promotes a healthy stress response*
  • Helps maintain healthy metabolic health*
  • Supports muscle function & recovery

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Our Most Advanced Magnesium Breakthrough

Woman holding Magnesium Breakthrough Advanced 10 supplement bottle

Evolution is in our DNA. So we decided to see if we could push the science even further.

We tracked down every new form of magnesium we could find and tested them one by one. Then we tested combinations, with the goal of maximizing bioaccessibility and bioavailability to design the most complete, whole-body magnesium support.

Two years and 5,500 experiments later, we finally cracked the code.

  • We’ve gone from 7 magnesium forms to 10.
  • We increased elemental magnesium from 500mg per serving to 550mg.
  • And here’s the big one: we nearly doubled bioaccessibility in our laboratory results.

What this means is that we may be helping your body access more magnesium in every serving.*

Why Did We Include 10 Forms of Magnesium?

Because if you want complete support for more restorative sleep, metabolic health, muscle recovery, and a healthy stress response, you need multi-pathway support.

Think of single-form magnesium as one key for one lock. Magnesium Breakthrough Advanced carries 10 keys to unlock more doors, helping provide broad-spectrum magnesium support across multiple systems of the body.*

Circular diagram showing 10 forms of magnesium in Magnesium Breakthrough Advanced: Glycinate, Citrate, Taurate, Chelate, Orotate, Malate, Sucrosomial, BHB, Caprylate, and Aspartate

Plus 3 more to round out the
complete formula

Find Your Magnesium Breakthrough

Forms of
Magnesium

Amount of
Magnesium

Best For

What It Does

Magnesium Breakthrough Capsules bottle

Magnesium Breakthrough Capsules

7

Forms

500mg

Elemental Magnesium

Foundational support for everyday sleep and stress

Supports sleep, relaxation, stress resilience, and recovery*

Learn More
Magnesium Breakthrough Powder tub

Magnesium Breakthrough Powder

8

Forms

325mg

Elemental Magnesium

A calming ritual you can look forward to drinking any time of day or night*

Supports calm, sleep, and stress resilience in a delicious drinkable form*

Learn More
Magnesium Breakthrough Advanced 10 Capsules bottle

Magnesium Breakthrough Advanced 10 Capsules

10

Forms

550mg

Elemental Magnesium

Most complete whole-body support for heavy stress, sleep disruption, travel, or when life demands more from you

Supports restorative sleep, relaxation, stress resilience, recovery, and metabolic health*

Add to Cart

Why Magnesium Breakthrough Advanced 10

Magnesium supports hundreds of functions throughout the body — energy production, muscle function, nervous system activity, cardiovascular physiology, glucose metabolism, bone health, immune function, and healthy sleep physiology.*

Yet many adults don’t get enough through diet alone. Modern eating habits, processed foods, agricultural practices, stress, aging, physical activity, and certain medications can all increase the body’s demand for magnesium.*

Most magnesium supplements rely on only one or two forms. But magnesium compounds differ — in solubility, gastrointestinal tolerance, dissolution behavior, and bioaccessibility. That’s why Advanced 10 combines 10 complementary forms rather than depending on a single source.*

Advanced 10 delivers:

  • 10 complementary forms of magnesium
  • 550 mg elemental magnesium per serving
  • Active vitamin B6 as Pyridoxal-5-Phosphate (P5P)
  • Ionic trace minerals
  • Identity, bioaccessibility, and bioavailability testing built into formulation*

The goal isn’t just to provide magnesium — it’s to support whole-body magnesium status through thoughtfully selected, complementary ingredients.*

Ingredients

Vitamin B6 (as Pyridoxine-5-Phosphate), Magnesium Proprietary Blend (Magnesium Chelate, Magnesium Glycinate, Sucrosomial® Magnesium (as Magnesium Oxide), Magnesium Malate, Magnesium Orotate, Magnesium Taurate, Magnesium Citrate, Magnesium Aspartate, Magnesium BHB, Magnesium Caprylate), Manganese (as Manganese Citrate), Ionic Trace Mineral Complex. Other Ingredients: Hypromellose (Capsule), Microcrystalline Cellulose, Ascorbyl Palmitate, goMCT® (medium chain triglycerides), gum acacia.

Magnesium Breakthrough Advanced 10 — supplement bottle
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.5 inches
  • Height: 4 inches
  • Bottom diameter: 2 inches
  • Weight: 3.05 ounces

Caution:

Use only as directed. Keep out of reach of children. Do not use if safety seal is broken or missing. Consult your healthcare practitioner before use if pregnant, nursing, taking medication, or under medical supervision. Discontinue use if adverse reactions occur.

Magnesium Breakthrough Advanced 10 — full product label
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365-Day Money Back Guarantee

All BIOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BIOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we’ll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

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CEO/Co-Founder of BIOptimizers

MAGNESIUM BREAKTHROUGH ADVANCED 10 reviews

Scientific Studies

  1. Brilli, E., et al. "Magnesium bioavailability after administration of sucrosomial® magnesium: results of an ex-vivo study and a comparative, double-blinded, cross-over study in healthy subjects." European Review for Medical & Pharmacological Sciences 22.6 (2018).
  2. Chacko, Sara A et al. "Magnesium supplementation, metabolic markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals." The American journal of clinical nutrition vol. 93,2 (2011): 463-73. doi:10.3945/ajcn.110.002949 https://doi.org/10.3945/ajcn.110.002949
  3. Dimai, H P et al. "Daily oral magnesium supplementation on bone turnover in young adult males." The Journal of clinical endocrinology and metabolism vol. 83,8 (1998): 2742-8. doi:10.1210/jcem.83.8.5015 https://doi.org/10.1210/jcem.83.8.5015
  4. Golf, S W et al. "On the significance of magnesium in extreme physical stress." Cardiovascular drugs and therapy vol. 12 Suppl 2 (1998): 197-202. doi:10.1023/a:1007708918683 https://doi.org/10.1023/a:1007708918683
  5. Dmitrašinović, Gordana et al. "ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation." Journal of medical biochemistry vol. 35,4 375-384. 2 Nov. 2016, doi:10.1515/jomb-2016-0021 https://doi.org/10.1515/jomb-2016-0021
  6. Held, Katja et al. "Oral Mg(2+) supplementation on age-related neuroendocrine and sleep EEG changes in humans." Pharmacopsychiatry vol. 35,4 (2002): 135-43. doi:10.1055/s-2002-33195 https://doi.org/10.1055/s-2002-33195
  7. Human Foods Program. "Qualified Health Claim Magnesium Reduced Risk of High Blood Pressure." U.S. Food and Drug Administration, 2024, https://www.fda.gov/food/hfp-constituent-updates/fda-announces-qualified-health-claim-magnesium-and-reduced-risk-high-blood-pressure. Accessed 9 July 2026.
  8. Joris, Peter J et al. "Long-term magnesium supplementation improves arterial stiffness in overweight adults: results of a randomized, double-blind, placebo-controlled intervention trial." The American journal of clinical nutrition vol. 103,5 (2016): 1260-6. doi:10.3945/ajcn.116.131466 https://doi.org/10.3945/ajcn.116.131466
  9. Kappeler, Dominik, et al. "Higher Bioavailability of Magnesium Citrate as Compared to Magnesium Oxide Shown by Evaluation of Urinary Excretion and Serum Levels after Single-Dose Administration in a Randomized Cross-Over Study." BMC Nutrition, vol. 3, no. 1, Jan. 2017, https://doi.org/10.1186/s40795-016-0121-3.
  10. Numydia Cotry, et al. "Effects of Intuitive Eating Principles and Magnesium Glycinate on Quality of Life, Body Satisfaction, and Stress in Early- and Middle-Aged Adults." TheScholarsRepository@LLU: Digital Archive of Research, Scholarship & Creative Works, 2024, https://scholarsrepository.llu.edu/rr/44/. Accessed 9 July 2026.
  11. Reno, Alyssum M et al. "Effects of Magnesium Supplementation on Muscle Discomfort and Performance." Journal of strength and conditioning research vol. 36,8 (2022): 2198-2203. doi:10.1519/JSC.0000000000003827 https://doi.org/10.1519/JSC.0000000000003827
  12. Schuette, S A et al. "Bioavailability of magnesium diglycinate vs magnesium oxide" JPEN. Journal of parenteral and enteral nutrition vol. 18,5 (1994): 430-5. doi:10.1177/0148607194018005430 https://doi.org/10.1177/0148607194018005430
  13. Schutten, Joëlle C et al. "Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial." Clinical endocrinology vol. 94,2 (2021): 150-157. doi:10.1111/cen.14350 https://doi.org/10.1111/cen.14350
  14. Schuster, Julius et al. "Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial." Nature and science of sleep vol. 17 2027-2040. 30 Aug. 2025, doi:10.2147/NSS.S524348 https://doi.org/10.2147/NSS.S524348
  15. Setaro, Luciana, et al. "Magnesium Status and the Physical Performance of Volleyball Players: Effects of Magnesium Supplementation." Journal of Sports Sciences, vol. 32, no. 5, Sept. 2013, pp. 438-45, https://doi.org/10.1080/02640414.2013.828847.
  16. Steward, Charles James et al. "One week of magnesium supplementation lowers IL-6, muscle discomfort and increases post-exercise blood glucose in response to downhill running." European journal of applied physiology vol. 119,11-12 (2019): 2617-2627. doi:10.1007/s00421-019-04238-y https://doi.org/10.1007/s00421-019-04238-y
  17. Veronese, Nicola et al. "Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial." The American journal of clinical nutrition vol. 100,3 (2014): 974-81. doi:10.3945/ajcn.113.080168 https://doi.org/10.3945/ajcn.113.080168
  18. Walker, Ann F., et al. "Magnesium supplementation on fluid retention." Journal of women's health 7.9 (1998): 1157-1165.
  19. Walker, Ann F et al. "Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study." Magnesium research vol. 16,3 (2003): 183-91.
  20. Wienecke, Elmar, and Claudia Nolden. "Langzeit-HRV-Analyse zeigt Stressreduktion durch Magnesiumzufuhr" [Long-term HRV analysis on stress by magnesium intake]. MMW Fortschritte der Medizin vol. 158,Suppl 6 (2016): 12-16. doi:10.1007/s15006-016-9054-7 https://doi.org/10.1007/s15006-016-9054-7
  21. Zogović, Dušanka, et al. "Pituitary-Gonadal, Pituitary-Adrenocortical Hormones and IL-6 Levels Following Long-Term Magnesium Supplementation in Male Students." Journal of Medical Biochemistry, vol. 33, no. 3, July 2014, pp. 291-98, https://doi.org/10.2478/jomb-2014-0016. Accessed 9 July 2026.