Never eat a carb without THIS Again

Support Healthy Blood Sugar Response, and Minimize Energy Dips and Sugar Cravings

You might think I’m crazy for saying that a plant could mimic the effects of fasting without fasting… but it’s true.

And in just a few short minutes I’ll prove it to you – with cold hard evidence. The facts. The science. The undeniable proof.

This plant does some weird, but wonderful, things to your body.

And no, it’s not magic mushrooms.

This stuff is completely legal…

And until recently, we’ve used it all wrong.

Now we’ve learned that it’s the key to unlocking your metabolism…

As well as protecting your cells from suboptimal diet and lifestyle.

It can even balance blood sugar, no matter how many pancakes you eat for breakfast.

And banish the afternoon slump so you can sustain lasting energy and focus at work.

It’s so powerful, you’d think it came from a lab, created by a mad scientist. Instead, Mother Nature has given us this gift.

Before I reveal the name, let me show you exactly how it works.

You’ll never want to eat another carb without this…

The Master Metabolic Switch That Controls Weight Loss & Aging

Imagine a switch in every cell of your body.

Fat cells, muscle cells, skeletal cells… everything.

When it’s flipped on, your body does some pretty amazing things.

Things like releasing fat and balancing immune functions.

It also kickstarts autophagy. Autophagy is your body’s way to clean out damaged cells and replace them with new and healthy ones.

All the things we want.

But when this switch is turned off… your body does the opposite.

Your health becomes suboptimal.

Blood sugar response can fluctuate… still within normal range but it becomes suboptimal.

And you get more oxidative stress.

Not good.

So how do you keep the switch turned on?

There are three things you can do:

1. Prolonged fasting

2. Significant calorie restriction

3. Strenuous exercise

Doesn’t sound all that appealing, does it?


Makes you feel like your only hope for achieving those goals would be to hop on the treadmill for 8 hours and just barely nibble on your food throughout the day like a little chipmunk.

Not so fast…

What if there was a way to trick your body into turning on the switch without fasting, dieting, or strenuous exercise?

Well, there is, and it’s called…


AMPK is not a drug.

It’s an enzyme hidden within every cell of your body that acts as a master control switch for everything… from weight loss to aging.

And its job is to maintain body homeostasis between energy consumption (hunger) and energy production (desire to exercise).

And subconsciously, it controls a lot more of your daily activities than you realize.

If you fight late-night hunger, afternoon slumps, or lack motivation to exercise…

AMPK could be the solution.

However, solving the problem with AMPK isn’t always so simple, because AMPK can be influenced by so many factors.

Things like diet, exercise, sleep, stress, age, and even genetics.

What we do know, however, is that AMPK clearly declines with age – leaving you more susceptible to energy swings, weight gain, and brain fog as you get older. [1]

That’s why many have turned to fasting to combat aging.

Does Fasting Turn On AMPK?

Unintentionally, millions of people around the world have been getting the benefits of AMPK activation through fasting.

However, the more popular intermittent fasting isn’t as much of a potent activator as some might hope.

A study showed that it takes 24 hours of fasting to get the benefits of AMPK and autophagy.[2]

Yet it seems nearly everyone is talking about intermittent fasting. Heck, 1 in 4 US adults said they tried it for fat loss.

Now just imagine if you could tap into…

The Full Power of AMPK

Kickstart Autophagy [4]

Many studies have proven AMPK to be a powerful driver to increase lifespan, some by as much as 15% [10]

One of the major benefits of fasting is cell recycling — out with the old, in with the new. AMPK triggers autophagy which is known as one of the most potent drivers to look younger and slow aging at the cellular level.[11]

Now just imagine if you could tap into…

The Full Power of AMPK

Kickstart Autophagy [3]

One of the major benefits of fasting is cell recycling – out with the old, in with the new.

AMPK triggers autophagy which is known as one of the most potent drivers to look younger and slow aging at the cellular level.

Burn Fat [4]

Not only does AMPK stop glucose from being stored, it also blocks metabolic pathways that store and create fat cells [5, 6]

Boost Athletic Performance [7]

The World Anti-Doping Agency has actually banned substances known to boost AMPK for their performance-enhancing properties.

Supports Healthy Insulin Level[8]

Exercise can promote insulin sensitivity and help you use carbs for energy, instead of storing them as fat.

But without AMPK, exercise won’t increase insulin sensitivity.

Avoid Oxidative Damage [9]

Because this enzyme ramps up the production of powerful antioxidants, like NFR2, it plays a critical role in fighting free radicals.

Live Longer [10]

Many studies have proven AMPK as a powerful driver to increase lifespan, some by as much as 15%.

Look Younger [#]

Glycation End Products (AGEs) from suboptimal blood sugar response can weaken elastin and collagen in your skin. This can accelerate skin aging, leading to aged and wrinkled appearance. AMPK can stop this process by helping to optimize your blood sugar response and protecting your tissues from AGEs. [11]

Because of its ability to create such life-changing effects in the body, AMPK has been given many nicknames – like magic bullet, metabolic thermostat, and youth switch.

Unfortunately, the modern world we live in is a very tough environment to keep the switch on.

This Shuts Off AMPK, Making It Nearly Impossible To Lose Weight

Let’s say you sleep your 8-9 hours, eat super healthy, and get in some form of exercise nearly every day…

There’s still a factor in our modern culture that you can’t avoid: stress.

Stress is bad. Everyone knows that. But why?

When we’re stressed, our bodies turn up hormones that increase blood sugar… even when we don’t eat.

Stress from work. Stress from family. Stress from lack of sleep. Doesn’t matter where it comes from… it’s nearly impossible to avoid.

Stress makes our cells less responsive to insulin. And when that happens, our bodies have to produce more insulin.

That’s a huge problem if you want to keep the AMPK switch on.

Because insulin is AMPK’s Kryptonite.

And in the presence of insulin, AMPK is in handcuffs.

It can’t and won’t give you the same powerful anti-aging and fat loss benefits you want.

So let’s recap…

Poor diet, lack of exercise, and stress can cause a rise in blood glucose.

When blood glucose is elevated (anytime you eat or get stressed), insulin is released.

If this happens consistently, our cells become less responsive to insulin, even though everything is still within normal range.

This blunts the effect of AMPK, the enzyme that keeps us young, healthy, and fit.

It’s harder to lose weight, avoid energy crashes, and fight against wrinkles.

But YOU have a choice.

You can follow in the footsteps of those who look decades younger and have more energy than ever before.

Now before I tell you what’s behind door number 2…
Let me clear something up.

Just because your tests came back normal and you aren’t obese…

Does NOT Mean That You’re in the Clear.

Even skinny, fit, and otherwise healthy people still suffer from stress. They still struggle to stay asleep at night. Their job or kids might get on their nerves.

And then it begins to show – under their eyes, around their waist, or maybe through the thinning hairs on their head.

Just because your test results aren’t out of range yet… don’t wait for them to be. Don’t wait for the underlying symptoms to pile up.

Otherwise, it could be a problem running in the background for years… and then it’s too late.

Like when a process called glycation happens – where your skin begins to wrinkle because the elevated glucose mixes with collagen in your skin cells.

So why wait?

Suboptimal insulin response and blood sugar balance can affect you tomorrow when you wake up, causing mood swings, energy crashes, and sugar cravings.

So without boring you with all the scientific jargon, just know this:

The more insulin sensitive you are…

The less your body needs to use food for energy…

The more that AMPK switch can be turned on…

The easier it is to lose weight, look younger, and boost energy

If You’re Experiencing Any of the Following…

Afternoon fatigue
Post-meal slump
Sugar cravings
Hunger after meals
Need your coffee
Lack of motivation
Poor sleep
Can’t lose weight

Just know that there are tens of millions – if not hundreds of millions – of people experiencing the same issues in the US alone.

Most of them ignore it and it becomes their normal. They can’t even remember what “feeling good” really feels like.

That’s why you discover people later in life wishing they would have done something sooner.

But I know that’s not you, otherwise you wouldn’t still be reading.

So, like I said before, you have another option…

Want to see what’s behind door number two?

Activate AMPK and Mimic Fasting Without Fasting… Naturally

As you might already assume, a lot of people would love to experience the benefits of fasting, without going actually fasting or trying something super risky.

So there has been a lot of talk around this natural alternative…

A substance extracted from a plant called goldenseal, which grows in the eastern United States.

Its name?


Maybe you’ve heard of it, maybe you haven’t.

It’s been used for decades in Chinese and Ayurvedic medicine with proof of effectiveness and safety, so you don’t need a prescription or doctor visit.

That’s why its prevalence in weight loss and glucose support supplements has skyrocketed in recent years.

However, it does have some flaws.

The main one is its poor bioavailability. The body simply can’t utilize all the benefits present in its traditional form.

That’s why scientists set out to increase bioavailability, and a new scientific discovery isolated the active compound in berberine.

It’s called Dihydroberberine (or DHB for short), and it’s a derivative of berberine that’s more bioavailable.

In fact, it’s 5x more powerful than traditional berberine, without the potential GI distress. [12]

No Wonder Why They Call It “The Super Berberine”

The tough part is getting your hands on it, since it’s patented. But we didn’t stop there…

To help me test the all-star lineup of formulations, I contacted a genius in the field, Dr. Dominic D’Agostino.

He’s an expert in Molecular Pharmacology and Physiology and a Research Scientist at the Institute for Human and Machine Cognition.

When Dr. Dom isn’t developing new metabolic-based strategies to combat everything from epilepsy to neurodegenerative diseases to cancer, he’s also an Associate Professor at the University of South Florida Morsani College of Medicine.

And the formula that we created was…



The first AMPK activator with DHB (The Super Berberine) designed to mimic the effects of fasting, slow aging, and accelerate weight loss.

Berberine Breakthrough not only includes DHB but also 3 other patented, clinically-studied, and doctor-recommended ingredients.

Glucovantage® Dihydroberberine (DHB)

The secret of berberine is DHB. While berberine has become a very popular product for weight loss and glucose control, DHB has been shown to be 5 times more powerful.

Glucovantage® DHB has been shown to:

Improve insulin sensitivity via AMPK activation.

Support healthy blood glucose and insulin levels

Support reducing glycation correlated with aging

Improve body composition and nutrient partitioning in combination with diet and exercise

Cinnulin PF® Cinnamon Bark 20:1

Cinnamon has been well-studied to support healthy blood sugar, blood pressure, and mental performance. One study showed a 20-fold improvement in glucose metabolism. [13]

However, unlike typical cinnamon, Cinnulin PF® is a water-soluble extract using Controlled Polymer Purification Technology. With this process, it isolates and potentiates the active ingredients, while avoiding the potential toxins from whole cinnamon.

Cinnulin PF® has been clinically shown to:

Support optimal blood sugar control already within normal range

Promote healthy body composition in combination with diet and exercise

Promote healthy blood pressure already within normal range

And support women’s hormone balance.[14]

Innoslim® Blend of Panax notoginseng & astragalus membranaceus

Innoslim® is a stimulant-free ingredient patented and developed to support healthy weight and glucose metabolism.

One of the major reasons it works so well compared to other stimulant fat burners is its powerful effects on AMPK.

InnoSlim® goes to work for you inside the body to nourish the cells with abundant nutrients to foster a healthy metabolic environment – and most of all to rid yourself of any unwanted fat.

Here are the research-backed benefits of Innoslim®:

Reduce glucose absorption by 46%

Increase AMPK by 23%

Increased ACC by 100% – a powerful mediator for weight.

Expect to experience less hunger, a change in weight, and steady energy levels when using Innoslim®

13 Research-Backed Ingredients

To Flip the Switch on Aging & Weight Loss

Berberine Breakthrough includes ingredients specifically chosen to balance blood glucose, improve insulin sensitivity, and increase AMPK activation including:

Banaba Leaf Extract






Irvingia Gabonensis
and Naringin

G. Sylvestre Extract


Berberine Breakthrough includes ingredients specifically chosen to balance blood glucose, improve insulin sensitivity, and increase AMPK activation including:

Banaba Leaf Extract






Gymnema Sylvestre leaf Extract

And we put Berberine Breakthrough to the test, so you could see for yourself the significant difference it can make. Just look at the graph…

Berberine Breakthrough vs Baseline

Taking Berberine Breakthrough helped stabilize blood sugar levels significantly before and after meals.

So let me ask you a question…

How much would you pay to get the anti-aging and fat loss benefits of fasting 365 days of the year without having to fast?

How much easier would it be to lose weight if you didn’t have to fight hunger pangs, sugar cravings, and energy swings?

How much more productive would you be if you didn’t have a post-meal slump, 2:30 “need a nap” feeling, or brain fog?

You deserve to experience productivity and lasting energy while maintaining stable blood sugar.

Berberine Breakthrough

Does not cause the same GI distress that other solutions might.

Does not inhibit the benefits of exercise or a healthy diet. (And as a 3-time All-Natural bodybuilding champion, it’s something I can stand behind.)

100% natural, with no synthetic additives, preservatives, or chemicals.

No prescription required, so anyone can experience the power of our 13 research-backed ingredients

That’s Why I’m So Proud to Stand Behind Berberine Breakthrough.

Our team at BIOptimizers created an industry-leading natural alternative to what was once not available to the average citizen.

But now you, from the comfort of your home, can get the same powerful anti-aging and weight loss benefits while helping optimize your blood sugar levels and manage your carb intake.

Plus, if you’re like me, I’m looking for every edge I can get. Especially as I get older.

When I saw not just one, but four, patented and clinically backed ingredients, the first thought that ran through my mind was… this is gonna cost a fortune.

And with nine other powerful ingredients that have been used around the world for centuries, I worried whether this product would be affordable for anyone.

Luckily I was wrong.

You can experience Berberine Breakthrough for yourself without breaking the bank.

Try Berberine Breakthrough RISK‑FREE


5 Bottles

Berberine Breakthrough


$41/ bottle

($204 TOTAL)

Save 32% + FREE SHIPPING (US & CA)

365-Day Money Back Guarantee

1 Bottle

Berberine Breakthrough


$53/ bottle

($53 + S&H)

Save 12%

365-Day Money Back Guarantee


3 Bottles

Berberine Breakthrough


$44/ bottle

($131.40 TOTAL)


365-Day Money Back Guarantee

Turn the switch on AMPK, put a pause on aging and look younger, and get the benefits of fasting without fasting… for a couple of bucks a day.

You don’t even have to say yes today, just maybe.

That’s right — give Berberine Breakthrough a try risk-free.

Berberine Breakthrough is so effective…

We Unconditionally Guarantee It for 365 Days

We understand you might be skeptical. But you’ve seen the research. We’ve packed the absolute, most powerful, clinically studied ingredients into one capsule and have made it available without breaking the bank.

Plus, our company — BIOptimizers — has been in business for full years. We stand behind our products and guarantee that they will do what we say they do.

And to make sure you have plenty of time to give our product a fair shot and make your decision, we’re giving you 365 days to decide.

In the highly unlikely event you’re not blown away, we refuse to keep even a penny of your money.

If you purchase 1 bottle and you are not completely satisfied, within 365 days you may request a full refund (minus shipping & handling cost).

If you choose to save money and buy a bundle of multiple bottles, you are still covered by a 365 day guarantee. If after your first bottle you are not satisfied, you can return your remaining unopened bottles within 365 days of purchase and we will issue you a full refund for your order (minus the cost of shipping & handling)*.

*Please note: If you open a second bottle, you no longer qualify for the guarantee above. Speak with our customer service team, and you may be able to receive a prorated refund depending upon the number of unopened bottles you will be returning.

Just contact us, let us know where we could be better, and we will issue you a refund (excluding any shipping and handling charges).

No questions asked.

Free Instant Access To The Most Valuable Health Community On The Internet The BIOtribe Family

As a valued BIOptimizers client you’ll automatically be invited to join the BIOtribe community, where we give our incredible BIOfam the space to:

The BIOtribe is a FREE, private Facebook group that provides the opportunity to truly bond with us AND the rest of our legendary BIOfam.

There’s ZERO COST to be in this BIOtribe. There are health groups that charge hundreds of dollars a year for less valuable communities. This is a string-free gift to all BIOptimizers customers, which includes YOU with your purchase of Magnesium Breakthrough.

In this group you will get access to:

Deep dives into various topics and Live Q&A’s EACH WEEK with amazing health experts that charge thousands for their advice

Exclusive “BIOtribe Only” content that you won’t find anywhere else

Monthly prizes and giveaways to the most valuable community members

And so much more…

We truly treasure your business and support. And we are incredibly excited to bring you more content and motivation in the BIOtribe to help you achieve all of your health goals.

Just be sure to use the same email address you use to make your Berberine Breakthrough purchase so we can verify you as part of our community.


How to Take Berberine Breakthrough for Maximum Results

If you want to maximize the benefits of Berberine Breakthrough we suggest you take it with meals (especially your big meals) to blunt the insulin response.

That way, you won’t experience the post-meal fatigue or dips in energy later.

Also, if you happen to intermittent fast and would like to get in a fasted state quicker, take Berberine Breakthrough 1-2 hours before bedtime.

With lower insulin levels and balanced blood sugar at night, you’ll experience more restful uninterrupted sleep.

Use Berberine Breakthrough to Beat Aging and Weight Loss With AMPK

This is why we worked so hard, researching the purest, most potent source of Berberine and other clinically studied ingredients and made it available to you, at the best possible price.

Save and get started with Berberine Breakthrough using on this page.

Your energy, metabolism, body fat, skin…

Indeed EVERY cell in your body… will thank you for it.

Wade Lightheart

President and Co-Founder of BIOptimizers

Advisor to the American Anti-Cancer Institute

Certified Nutritionist

Author of the Best Selling Book 'Staying Alive In A Toxic World'

3-Time All Natural National Bodybuilding Champion

P.S. If you’re still not convinced of the power of Berberine Breakthrough, just look at all of these studies (links below) — it’s everything we’ve referenced in this letter and more…

Click Here to see some of the amazing research showing why Berberine Breakthrough is one of the most powerful supplements you can take

[1] Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012 Apr;11(2):230-41. doi: 10.1016/j.arr.2011.12.005. Epub 2011 Dec 15. PMID: 22186033.

[3] Federico Pietrocola, Yohann Demont, Francesca Castoldi, David Enot, Sylvère Durand, Michaela Semeraro, Elisa Elena Baracco, Jonathan Pol, Jose Manuel Bravo-San Pedro, Chloé Bordenave, Sarah Levesque, Juliette Humeau, Alexis Chery, Didier Métivier, Frank Madeo, M. Chiara Maiuri & Guido Kroemer (2017) Metabolic effects of fasting on human and mouse blood in vivo, Autophagy, 13:3, 567-578, DOI: 10.1080/15548627.2016.1271513

[3] Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81. PMID: 27416781; PMCID: PMC4973318.

[4] Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81. PMID: 27416781; PMCID: PMC4973318.

[5] Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81. PMID: 27416781; PMCID: PMC4973318.

[6] AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

[7] Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L. AMPK in skeletal muscle function and metabolism. FASEB J. 2018 Apr;32(4):1741-1777. doi: 10.1096/fj.201700442R. Epub 2018 Jan 5. PMID: 29242278; PMCID: PMC5945561.

[8] Jensen J, O'Rahilly S. AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles. Mol Metab. 2017 Feb 1;6(4):315-316. doi: 10.1016/j.molmet.2017.01.012. PMID: 28377870; PMCID: PMC5369262.

[9] Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81. PMID: 27416781; PMCID: PMC4973318.

[10] Shirwany NA, Zou MH. AMPK: a cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed). 2014 Jan 1;19:447-74. doi: 10.2741/4218. PMID: 24389195; PMCID: PMC4101001.

[11] Lin CH, Cheng YC, Nicol CJ, Lin KH, Yen CH, Chiang MC. Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells. Exp Cell Res. 2017 Oct 15;359(2):367-373. doi: 10.1016/j.yexcr.2017.08.019. Epub 2017 Aug 15. PMID: 28821394.

[12] What is GlucoVantage.

[13] J. Agric. Food Chem. 2004, 52, 1, 65–70 Publication Date:December 3, 2003

[14] What is CINNULIN PF®?