I have struggled for half my life with stomach issues. My doctor told me I had IBS in my 20's but only recommended I take Metamucil. That didn't help so I decided to try OTC probiotics. That gave me minimal improvement. Things got so bad that when I went out, I always looked to see where the bathroom was before getting comfortable. My stomach (ranging from constipation, cramping to serious diarrhea) problems were controlling my life. I was listening to Melanie Avalon's Biohacking podcast when she had the owner of BioOptimizers on. I was impressed and thought I would give it a try - especially since I have also been reading about the gut-brain connection and I was getting desperate - even thought I may have colitis. Not to be gross, but I hadn't had a "normal" poop for as long as I can remember. It wasn't long before that changed. No straining anymore - it just came out smooth as can be and required almost no TP afterward. I can't tell you how much better I feel because my stomach feels good. It's all connected but the gut is driving the body. I am sold and am only writing a review because if you have felt anywhere near as miserable as I have, I hope you give it a try and see how much better you can feel again. For me, P3OM was life changing!