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  • Increases blood sugar uptake into muscles rather than fat cells
  • Improves exercise performance and muscle gain
  • Supports healthy blood sugar control and insulin response
  • Improves carbohydrate metabolism
  • Improves energy level and overall well-being
  • Neutralizes oxidative damage from high blood glucose
  • Supports weight loss effort in combination with diet and exercise
  • Balances hormones and stress response from blood sugar fluctuations
  • Normalizes mood swings, energy swings, brain fog, and cravings due to blood sugar fluctuations
  • Increases mitochondrial uncoupling, which burns more calories as heat
  • Promotes healthy carbohydrate digestion and absorption in the gut
  • Promotes a balanced inflammatory response

BERBERINE BREAKTHROUGH

Blood Sugar Balance & Support Supplements

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  • Increases blood sugar uptake into muscles rather than fat cells
  • Improves exercise performance and muscle gain
  • Supports healthy blood sugar control and insulin response
  • Improves carbohydrate metabolism
  • Improves energy level and overall well-being
  • Neutralizes oxidative damage from high blood glucose
  • Supports weight loss effort in combination with diet and exercise
  • Balances hormones and stress response from blood sugar fluctuations
  • Normalizes mood swings, energy swings, brain fog, and cravings due to blood sugar fluctuations
  • Increases mitochondrial uncoupling, which burns more calories as heat
  • Promotes healthy carbohydrate digestion and absorption in the gut
  • Promotes a balanced inflammatory response
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Why Is Berberine Breakthrough The Best?

  • Synergy of science-backed blood sugar control ingredients at doses shown to be clinically effective
  • The formula addresses all biochemical pathways related to blood sugar control at the cellular level, making it highly potent
  • Clinically tested to potently normalize blood sugar response
  • Designed to help you live an awesome life enjoying your favorite high-carb foods with maximal muscle gains and minimal health risks
  • 100% natural and drug-free

INGREDIENTS:

CyanthOx™ 30 Hippophae rhamnoides L (fruit), Extract (30% proanthocyanidins), Irvingia gabonensis (seed), Naringin, Benfotiamine, R-Alpha Lipoic Acid, Banaba (leaf) Extract (20% corosolic acid), Gymnema sylvestre (leaf) Extract, Fucoxanthin 10%, Bitter Melon (fruit) Extract (10% charantin), GlucoVantage™ Dihydroberberine, Cinnulin PF™ Cinnamon (bark) 20:1 Extract, Innoslim™

Other Ingredients: Hypromellose (capsule), rice fiber, rice extract blend.

MANY OF PRODUCTS ARE:

Dairy Free
Dairy
Free
Gluten Free
Gluten
Free
Vegan
Vegan
Sugar free
Sugar
Free
Chemicals & Fillers Free
Chemicals &
Fillers Free
Natural Ingredients
All Natural
Ingredients
USA made
USA made with
globally-sourced
ingredients

Berberine Breakthrough Benefits

  1. Regulates Blood Sugar Rollercoaster

    Most people nowadays have some trouble with poor blood sugar balance from stress, inactivity, and suboptimal sleep. As a result, after a high-carbohydrate meal, their blood sugar can rise very high and cause many health problems.

    In the short term, the blood sugar dips cause energy crash, craving, fatigue, headache, dizziness, and “hangriness.” As a result, they may experience sugar cravings and reach for stimulants.

    In the long term, the blood sugar roller coasters can cause your cells to become resistant, and may lead to belly fat, metabolic syndrome, cardiovascular diseases, and many more issues.

    One way to stabilize is to create blood sugar balance by either eating fewer carbs or slowly absorbing carbohydrates. Berberine Breakthrough can significantly blunt the sugar cravings and energy rollercoaster.

  2. Increases Blood Sugar Uptake Into Muscle Cells

    When you have excess blood sugar, it can either go into your fat cells or muscles. Berberine Breakthrough is a synergistic blend of 10 glucose dispersal agents, which puts glucose into your muscle glycogen stores rather than as fat cells. As a result, the carbohydrates you eat help fuel your workout and support your muscle gains rather than causing fat gain.

    In addition, berberine, banaba, and cinnamon inhibit the production and differentiation (specialized development) of fat cells. Therefore, you’re less likely to gain fat even after high-carbohydrate meals or in a caloric surplus.

  3. Combats Oxidative Stress

    High blood sugar can increase oxidative stress, which ages your cells and creates inflammation. The herbs in Berberine Breakthrough, along with alpha-lipoic acid and propolis, have antioxidant activities, which can mitigate the harmful effects of oxidative stress.

  4. Supports Weight Loss Effort, Especially from Belly Fat

    Weight loss requires you to be in a caloric deficit, which means burning more than you eat. Berberine Breakthrough shifts your hormones and biochemistry toward burning more calories in the following ways:

    • Balances chronic inflammation - Chronic inflammation from unhealthy diets (metabolic endotoxemia) can cause leptin resistance, which may lead to weight gain. Many components of Berberine Breakthrough promotes a healthy inflammatory response and mitigates this effect.
    • Jumpstarts mitochondria - Many people who struggle with weight loss have sluggish mitochondria. Bitter melon extract can jumpstart the mitochondria by bringing fatty acids into the mitochondria, making fat burning more efficient. Also, by increasing a process called mitochondrial uncoupling, they use the energy to produce heat instead of other cellular processes.
    • Activates AMPK - AMPK is an energy sensor that activates fat burning. In Berberine Breakthrough, quercetin, berberine, ginsenoside Rb1, Alpha-lipoic acid, resveratrol, and cinnamon work together to activate AMPK.

    Overall, stabilizing blood sugar typically reduces the hunger, cravings, and moodiness that arise during blood sugar lows. You will also reduce your cortisol due to lower stress levels, making it easier to lose fat from the abdominal area. This should make it easier to stay on a healthy and caloric-deficit diet.

    Therefore, Berberine Breakthrough will make weight loss easier and more likely to last in addition to a healthy diet and exercise program.

  5. Supports Healthy Hormone Balance and Stress Response

    Constantly being on a blood sugar rollercoaster is very stressful to the body because the blood sugar lows put your body into an emergency response mode.

    Therefore, poor blood sugar control can cause hormone imbalances, worsening symptoms such as PMS, hot flashes, and low libido.

    It is critical to improve your blood sugar control if you want to balance your hormones and have a healthy stress response. Berberine Breakthrough should be an important tool in any hormone balancing toolbox.

  6. Supports Good Mood and Healthy Brain Function

    Your brain controls not only your thoughts but also many aspects of your physiology on autopilot. This takes a lot of glucose. It weighs 2% of your bodyweight but takes up to 20% of your daily calorie intake.

    As a result, your brain is exquisitely sensitive to major blood glucose fluctuation. Extreme blood sugar fluctuations can worsen anxiety, irritability, depression, brain fog, and even psychosis.

    While Berberine Breakthrough is not approved to treat any disease, minimizing blood sugar rollercoasters is critical for good brain health, mental health, and cognitive function.

  7. Anti-Aging

    Glucose is a type of oxidizing sugar, which means high blood glucose can increase oxidative stress and accelerate aging. If you want to live a long and healthy life, you want to keep your blood sugar even-keeled.

    By stabilizing blood sugar and providing a source of antioxidants, Berberine Breakthrough can be considered an anti-aging supplement.

How Does Berberine Breakthrough Work?

Berberine Breakthrough is the most comprehensive blood sugar supplement on the market because it addresses all cellular aspects of blood sugar control.

  1. Stimulates Glut4 Receptors

    Glut4 (Glucose transporter 4) receptors are present in fat, heart muscles, and muscle cells. Once receptors are stimulated, Glut4 are brought to the cell surface, allowing glucose to move into the cells.

    Ingredients in Berberine Breakthrough, including cinnamon, alpha lipoic acid, and banaba leaf extract help bring Glut4 to the cell surface.

  2. Activates AMPK

    AMPK is an energy sensor of your cells. When your cells have low ATP, AMPK will tell your cells to bring in more glucose into the cells. Berberine Breakthrough activates AMPK.

  3. Slows Down Carbohydrate Digestion and Absorption

    Components of banaba leaf, Innoslim, and bitter melon extracts have been shown to slow down the digestion of carbohydrates and absorption of glucose. As a result, Berberine Breakthrough can significantly reduce the glycemic impact of your meals, so you’re less likely to spike your blood sugar and crash.

  4. Increases GLP-1

    GLP1 (Glucagon-like peptide 1) has anti-inflammatory effects and counteracts the resistance caused by inflammation. Cinnamon in particular increases GLP-1.

  5. Acts Like Hormones That Manage Blood Sugar

    Seabuckthorn, bitter melon, and banaba leaf extracts have components that stimulate important signaling pathways, which help cells take up glucose from the bloodstream faster.

  6. Activates PPAR-Alpha and PPAR-Gamma

    PPAR-alpha and PPAR-gamma are proteins that turn on genes (transcription factors) that control metabolism. PPAR-alpha increases fat breakdown in the liver, and is typically activated during caloric restriction or ketosis. Whereas, PPAR-gamma activation typically increases sensitivity and secretion of critical factors for metabolic processes.

    Cinnamon, alpha-lipoic acid, bitter melon, and quercetin either increase or activate these proteins.

  7. Improves Mitochondrial Function and Uncoupling

    Bitter melons and fucoxanthin increase mitochondria fat breakdown and uncoupling, which leads to heat loss. Many animal studies have also found that bitter melon led to fat loss.

When To Take Berberine Breakthrough?

Take 2 capsules before each meal. Store in a cool/dry location.

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Muscle Building High Calorie Stack
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Frequently Asked Questions:

What are the normal blood sugar levels?

A normal fasting blood sugar level is under 100 mg/dL (5.6 mmol/L). However, levels under 86 mg/dL (4.8) is optimal or corresponds to lowest risk of disease and death.

How can I instantly lower my blood sugar?

Using a glucose disposal agent supplements or exercising, even walking, can help lower blood sugar.

What are foods that reduce blood sugar levels?

Bitter melon, fenugreek, cinnamon, garlic, and cold water fish may lower blood sugar levels.

How can l control my blood sugar?
  • Eat a healthy low-glycemic diet high in protein and fibers. (Low-carb and ketogenic diets are also low-glycemic.)
  • Exercise regularly and frequent movements throughout the day
  • Avoid sugar or foods that spike your blood sugar
  • Manage stress
  • Optimize sleep quality and quantity, which may involve seeing your doctor to screen for sleep disorders
  • Use a glucose disposal supplement such as Berberine Breakthrough
What are the reasons for high blood sugar?
  • Type 1 diabetes (autoimmune)
  • Resistance to important chemical signals in the body utilized in blood sugar metabolism
  • Eating a high-carb or high-sugar meals
  • Inactivity
  • Stressful lifestyle
  • Poor sleep or circadian rhythm
What should my blood sugar be when I wake up?

A normal fasting blood sugar level is under 100 mg/dL (5.6 mmol/L). However, levels under 86 mg/dL (4.8) is optimal or corresponds to lowest risk of disease and death.

What does it feel like to have extremely high blood sugar levels?

High blood sugar levels may have no symptoms. However, extremely high blood sugar could lead to thirst, frequent urination, and fatigue.

BERBERINE BREAKTHROUGH
  • Made in USA
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.58 inches
  • Bottom diameter: 1.95 inches
  • Height: 3.78 inches
  • Weight: 1.98 ounces

Caution:

Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you’re undergoing treatment of a medical condition.

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BERBERINE BREAKTHROUGH
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BERBERINE BREAKTHROUGH - 365-Day Money Back Guarantee

All BIOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BIOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we'll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

365 Money-Back Guarantee

Why BIOptimizers Is A Different Kind Of Company

  • "BEST IN CLASS" guarantee: Our mission is focused on customer obsession. If after trying our products you don't feel we are the BEST IN CLASS, we will refund your money.
  • We work with 5 world-class formulators to create the best in class formulas
  • Customers love us: 5000+ positive product reviews
  • 99.3% customer satisfaction
  • We have helped over 662,794 legendary customers optimize their health since 2004
  • The 365 Day “Best Product Ever Or Your Money Back” Guarantee
  • One of the fastest growing companies in the USA - 3 years in a row
  • Experienced customer service: our happy health concierges are happy to help via phone at (800) 719-2467 or email [email protected]

BIOptimizers Was Born From Pain And Passion

Wade’s passion and mission for helping others optimize their health started when he witnessed his 23-year-old sister pass away from cancer. It was a heart-breaking experience that shaped his destiny. That’s when he realized that health was the most precious asset we have in this life.

Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months. He watched his friend’s entire life transform as a result. He went from never having a girlfriend to being married in just a couple of years.

Wade Lightheart

Wade Lightheart

President

Matt Gallant

Matt Gallant

Chief Executive Officer

Wade and Matt were both trainers working with pro athletes and other high performers. They both spent a decade in the gym helping people transform their health. Wade and Matt met in the gym, struck a friendship, and then started a business partnership that has been going strong since 2004.

That’s right, we started selling fitness programs, digestive enzymes and organic plant-based protein in 2004. Our obsession to build the best-in-class formulas and solutions just gets stronger. Our policy is, “If we can’t build the best product in that category, forget about it.”

We’re willing to go ALL IN on the formulas. What does this mean? Our average cost per bottle is 200% to 400% higher than most of our competitors. We use the optimal, effective doses of the most researched ingredients. We know that once you experience the results, you’ll be a fan of BIOptimizers for life.

Matt & Wade Matt & Wade
Matt & Wade Matt & Wade
BIOptimizers-2022Inc5000

Thank YOU for helping us become one of the fastest-growing companies in America - 3 Years in a row.

Thank you for trusting us with your health.

matt-gallant

CEO/Co-founder of BIOptimizers

BERBERINE BREAKTHROUGH REVIEWS

Scientific Studies
  1. Wang C, Wang Y, Ma SR, et al. Berberine inhibits adipocyte differentiation, proliferation and adiposity through down-regulating galectin-3. Sci Rep. 2019;9(1):13415. Published 2019 Sep 16. doi:10.1038/s41598-019-50103-5
  2. Karsono AH, Tandrasasmita OM, Tjandrawinata RR. Bioactive fraction from Lagerstroemia speciosa leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis. J Exp Pharmacol. 2019;11:39-51. Published 2019 May 2. doi:10.2147/JEP.S181642
  3. Lee SG, Siaw JA, Kang HW. Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation. Foods. 2016;5(4):83. Published 2016 Dec 6. doi:10.3390/foods5040083
  4. Zakerkish M, Jenabi M, Zaeemzadeh N, Hemmati AA, Neisi N. The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial. Sci Rep. 2019 May 13;9(1):7289. doi: 10.1038/s41598-019-43838-8. PMID: 31086222; PMCID: PMC6514000.
  5. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi:10.1155/2015/496169
  6. Kim J, Yang G, Kim Y, Kim J, Ha J. AMPK activators: mechanisms of action and physiological activities. Exp Mol Med. 2016;48(4):e224. Published 2016 Apr 1. doi:10.1038/emm.2016.16
  7. Lowry, F., 2012. Hot Flashes Linked to Resistance. [online] Medscape.[Accessed 6 April 2021].
  8. Raichle ME, Gusnard DA. Appraising the brain's energy budget. Proc Natl Acad Sci U S A. 2002;99(16):10237-10239. doi:10.1073/pnas.172399499
  9. Ríos JL, Francini F, Schinella GR. Natural Products for the Treatment of Type 2 Diabetes Mellitus. Planta Med. 2015;81(12-13):975-994. doi:10.1055/s-0035-1546131
  10. Wang CW, Su SC, Huang SF, et al. An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression.Mol Pharmacol. 2015;88(6):1072-1083. doi:10.1124/mol.114.097352
  11. Hui H, Tang G, Go VL. Hypoglycemic herbs and their action mechanisms. Chin Med. 2009;4:11. Published 2009 Jun 12. doi:10.1186/1749-8546-4-11
  12. Hlebowicz J, Hlebowicz A, Lindstedt S, et al. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, glucose-dependent polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009;89(3):815-821. doi:10.3945/ajcn.2008.26807
  13. Gao S, Guo Q, Qin C, Shang R, Zhang Z. Sea Buckthorn Fruit Oil Extract Alleviates Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Cells and Rats. J Agric Food Chem. 2017;65(7):1328-1336. doi:10.1021/acs.jafc.6b04682
  14. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi:10.1155/2015/496169
  15. Zhao J, Zhou H, An Y, Shen K, Yu L. Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound. Oncol Lett. 2021;21(2):84. doi:10.3892/ol.2020.12345
  16. Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ. Improved Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors. PPAR Res. 2008;2008:581348. doi:10.1155/2008/581348
  17. Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007;16(3):291-302. doi:10.1517/13543784.16.3.291
  18. Chao CY, Huang CJ. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci. 2003;10(6 Pt 2):782-791. doi:10.1159/000073966
  19. Beekmann K, Rubió L, de Haan LH, et al. The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ). = Food Funct. 2015;6(4):1098-1107. doi:10.1039/c5fo00076a
  20. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi:10.1155/2015/496169
  21. Maeda H. Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: a review. J Oleo Sci. 2015;64(2):125-132. doi:10.5650/jos.ess14226

*These statements have not been evaluated by the Food and Drug Administration. Probiotic supplements are not drugs and therefore are not intended to diagnose, treat, cure, or prevent any disease or health condition.