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Biome Breakthrough® is a powerful combination of IgYmax and synbiotics (probiotics and prebiotics). It is synergistically designed to weed out bad bacteria and reseed the good ones, as well as repair the gut lining.

Vegetarian vanilla – powder complex – 30 servings (150 grams)



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delivered every
60 capsules

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Due to high demand, we recently ran out of Magnesium Breakthrough but we are back in FULL STOCK. Be aware, due to extreme demand it can take 3-5 days to ship it out. We appreciate your patience and understanding.

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Biome Breakthrough® is a powerful combination of IgYmax and synbiotics (probiotics and prebiotics). It is synergistically designed to weed out bad bacteria and reseed the good ones, as well as repair the gut lining.

Vegetarian vanilla – powder complex – 30 servings (150 grams)

Frequently Bought Together

A “Deathbed Story” That Changed The Way We Think About Immunity Forever...

Well, most people don’t realize this... but there are TWO theories out there about germs and immunity, NOT just one.

The first theory says that germs cause infections—but that doesn’t tell the whole story...

The second theory says, “Yes, germs can attack us”—and that’s not good...

But it’s ONLY really dangerous for those with an immune system that can’t prevent the infection due to the unhealthy gut terrain...

This is why, on his deathbed, Louis Pasteur supposedly told a fellow researcher:

“Le microbe n’est rien, le terrain est tout.” (The microbe is nothing, the terrain is everything).

“Le microbe n’est rien, le terrain est tout.” (The microbe is nothing, the terrain is everything).

Why Most Approaches To Supporting a Healthy Gut Terrain Immunity Fall Painfully Short

The second theory of immunity—which Pasteur admitted was more true—explains how two people can be exposed to EXACTLY the same pathogen...

And yet ONLY ONE actually gets sick...

The difference is usually that the person who stays well has stronger gut health and immunity...

It’s why I’ve literally not gotten the flu, or any other sickness, in 20+ years...

This is despite frequently traveling to India... Southeast Asia (including long trips in Bali and Thailand)... Latin American countries like Mexico... and many more...

That’s pretty much unheard of...

Because I discovered a way to strengthen my gut barrier and grow a healthy gut flora

Let me walk you through them, one-by-one so you can heal your gut and upgrade your immunity...


Forgive me for getting nerdy for a second... but this is essential to sealing any holes in your gut.

Immunoglobulins are a class of proteins which are formed by your immune system in reaction to certain foreign substances.

They are quite frankly some of the most powerful nutrients in existence.

Your body is specifically designed to recognize and USE immunoglobulins to help in the fight against pathogens.

But here’s the REALLY amazing part...

Specific immunoglobulins found in eggs have superpowers—especially when it comes to your gut.

In fact, one study conducted on an egg-based immunoglobulin—called IgY—found mind-blowing results:

Initially, the majority of subjects reported “a decrease in gas and bloating” and “felt more energy”...

Yet the most incredible result of all was the 95% decline in the occurrence of something called Zonulin—which shows up when there is excess intestinal permeability (holes in the gut lining)...

That means you...

Take This Nutrient, And Up To 95% Of The “Holes” In Your Gut Get Sealed...

Truly amazing.

Plus, subjects saw a 290% decline in leaky gut and cytokine markers—which speaks to how this rare compound delivers further benefits to your immune system, digestion, and more.

Now, you *could* definitely get more of this nutrient by eating more egg yolks—but there’s a problem...

These egg-based immunoglobulins are very sensitive to heat — so cooking up some delicious eggs isn’t that helpful...

Plus, to get enough of these immunoglobulins to actually repair gut lining and for them to pass through your entire gastric environment, with all of the acids it produces...

These immunoglobulins need to be attached to special sugars so they can reach your gut lining fully intact.

More on this in a moment...

GUT-IMMUNITY NUTRIENT #2: Rare “Repairing” Probiotic Strains

Once the lining in your gut is no longer excessively “permeable” (riddled with holes)... you’re ready for the next step.

Years and years of gut issues have left most people with a very toxic imbalance of bad microbes relative to the good guys.

And in this altered environment, where food tends to rot and putrefy more, the problem tends to get worse with time...

Luckily, in my work with thousands of clients and follow-up research with our team...

We uncovered the EXACT probiotic strains needed to kickstart this repopulation process...

This way, your gut lining is filled with all the good bacteria needed to help you build super immunity...

This includes:

GUT-IMMUNITY NUTRIENT #3: Feed The Good Guys Starved The Bad Guys With Powerful Prebiotics

The last step is simply to add prebiotics—which are nutrients/fuel for your friendly bacteria—to accelerate the regrowth and rebuilding process.

Unfortunately, not all prebiotics are created equally... so you need to be careful which ones you incorporate. Science says these are most effective:

Inulin - a naturally occurring polysaccharide sugar produced by many types of plants, which cannot be absorbed as a carbohydrate, and instead feeds friendly bacteria in your gut.

Inulin has some very impressive research behind it:

One study on inulin (and its fermentation metabolites) found that it boosted gut barrier and immune function of porcine intestinal epithelial cells...

A study published in the prestigious British Journal of Nutrition found that Inulin prebiotics directly helped modulate immunity function in humans...

And just like the probiotic strains we covered a moment ago, a study found that inulin can help with weight management and ectopic fat with subjects who have blood sugar issues...

Now, there are even more prebiotics you could add to this mix—but this is a great start.

Especially because this 1-2-3 combination goes beyond just restoring your gut-immunity connection.

It helps activate ALL FOUR critical pathways necessary for “super immunity.”

Why Settle For One Immunity Pathway When You Could ACTIVATE ALL 3?

You’ve probably seen more “immunity solutions” in recent months—than all the other years of your life combined.

Solutions like vitamin C... colloidal silver... elderberry... zinc... and many others.

Nothing against any of these nutrients; they can be great to take.

  • FIRST, they do NOT address the ROOT CAUSE of weak immunity , which lies in your gut permeability and balance... AND...
  • And SECOND, they ONLY activate ONE of the major pathways to immune response...

The three shortcut nutrient steps you’ve just discovered, on the other hand, activate all three pathways and thereby help build what I like to call “super immunity.”

This includes:

Nutritional Facts
  • Increases nutrient absorption
Suggested Use

Add one level scoop of Biome Breakthrough® to 8 oz. of water. Take once a day on an empty stomach.

Store in a cool and dry location.

Please consult a healthcare professional before beginning any new supplement, diet, or training program, or if you are undergoing treatment for a medical condition.

Frequently Asked Questions:

What are the Benefits of Biome Breakthrough®?

Biome Breakthrough is a synergistic blend designed to improve your gut microbiome and heal your gut lining.

IgYmax, a key component of LGG has been clinically shown to reduce the leaky gut marker Zonulin by 95%. Also, it improves the gut lining’s ability to break down histamine, which indicates reduced inflammation.

Many bad bacteria in your gut won’t leave because they camp out in their “biofilms,” which protect themselves from antimicrobials and your immune cells. IgYmax can disrupt these bad biofilms, while the good bacteria strains in LGG are good biofilm builders. Together, both the IgYmax and good bacteria strains help reshape your gut biome and create more good biofilms.

The prebiotics, collagen, and gelatin (for vanilla flavor) in BCC provide food for the good gut bacteria and nutrients that nourish the gut lining. The prebiotics improve the survival of good gut bacteria. Also, when the good bacteria ferment these nutrients, they provide beneficial and gut-healing substances such as butyrate.

Health benefits of Biome Breakthrough may include:

  • Better balanced immune responses
  • Less gut inflammation
  • Better nutrient absorption
  • Reduced bloating and gas
  • Better digestion

Some people may also find better energy levels, cognitive function, and results from their diet and workout programs. Because leaky gut manifests differently for everyone, individual responses vary.

When is the best time to take Biome Breakthrough®?

Biome Breakthrough® can be taken on an empty stomach upon waking to enjoy optimal benefits.

What is the recommended dosage for Biome Breakthrough®?

The recommended dosage for Biome Breakthrough® is one level scoop for one 8 oz. cup. Take once a day on an empty stomach.

Can children take Biome Breakthrough®? If so, what is the suggested dosage?

Biome Breakthrough® is not recommended for children.

How should Biome Breakthrough® be stored?

Store Biome Breakthrough® in a cool and dry location.

What is the shelf life for Biome Breakthrough®?

The shelf life for Gut Guardian® is 2 years from the manufactured date, which can be found on the bottle.

Is it okay for pregnant or breastfeeding mothers to take Biome Breakthrough®?

Pregnant or breastfeeding mother should consult a healthcare professional before beginning any new supplement, diet, or training program, or if you are undergoing treatment for a medical condition.

  • Made in USA
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.5 inches
  • Bottom diameter: 2 inches
  • Height: 4.5 inches
  • Weight: 3.6 ounces


Do not use if ulcer or gastritis are present.


BIOME BREAKTHROUGH® – VANILLA - 365-Day Money Back Guarantee

All BiOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BiOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we'll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

365 Money-Back Guarantee

Why BiOptimizers Is A Different Kind Of Company

  • "BEST IN CLASS" guarantee: Our mission is focused on customer obsession. If after trying our products you don't feel we are the BEST IN CLASS, we will refund your money.
  • We Work With 5 World-Class Formulators To Create The Best In Class Formulas
  • Customers Loves Us: 5000+ positive product reviews
  • 99.3% Customer Satisfaction
  • We have helped over 185,000 legendary customers optimize their health since 2004
  • The 365 Day “Best Product Ever Or Your Money Back” Guarantee
  • We are the 3rd fastest growing supplement company in the USA and the 245th fastest growing across all industries on the Inc. 5000 list.
  • Experienced Customer Service: Our happy health concierges are happy to help via phone at (800) 719-2467 or email [email protected]

BiOptimizers Was Born From Pain And Passion.

Wade’s passion and mission for helping others optimize their health started when he witnessed his 23-year-old sister pass away from cancer. It was a heart-breaking experience that shaped his destiny. That’s when he realized that health was the most precious asset we have in this life.

Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months. He watched his friend’s entire life transform as a result. He went from never having a girlfriend to being married in just a couple of years.

Wade Lightheart

Wade Lightheart


Matt Gallant

Matt Gallant

Chief Executive Officer

Wade and Matt were both trainers working with pro athletes and other high performers. They both spent a decade in the gym helping people transform their health. Wade and Matt met in the gym, struck a friendship and then started a business partnership that has been going strong since 2004.

That’s right, we started selling fitness programs, digestive enzymes and organic plant-based protein in 2004. Our obsession to build the best-in-class formulas and solutions just gets stronger. Our policy is, “If we can’t build the best product in that category, forget about it.”

We’re willing to go ALL IN on the formulas. What does this mean? Our average cost per bottle is 200% to 400% higher than most of our competitors. We use the optimal, effective doses of the most researched ingredients. We know that once you experience the results, you’ll be a fan of BiOptimizers for life.

Matt & Wade
Matt & Wade

Thank YOU for helping us become one of the fastest growing companies in America.

Thanks to your support, we are the 3rd fastest growing supplement company in the USA and the 245th fastest growing across all industries on the Inc. 5000 list.

Thank you trusting us with your health.


CEO/Co-founder of BiOptimizers