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Is Brain Fog Clouding Your Vision of a Better Life?

Brain fog and lack of mental clarity seem to be the biggest obstacles that stop us from achieving peak performance. Whether we want to give our best at work or simply enjoy life at its plentiest, being unable to fully focus on our goals is what truly sets us apart from achieving them. 

And the reason behind it is we’re neglecting to nurture our brain the same way we do our body.

But not anymore.

It’s time to feed the mind and body with the best brain-health promoters: Nootropics

And with it:

  • Boosting brain health, mental clarity, learning, memory, and focus by improving the gut bacteria
  • Eliminate brain fog and procrastination
  • Promoting relaxation and balanced stress responses
  • Enhancing cognitive function, mood and stress resilience by improving your gut flora
  • Balancing of neurotransmitters, including acetylcholine, serotonin, GABA and dopamine in the brain
  • Protecting the brain against oxidative stress
  • Improving blood flow to the brain
  • Supporting digestive health and regularity

WHAT ARE NOOTROPICS?
AND WHY SHOULD THEY BE A PART OF YOUR DIET?

Nootropics are substances known to improve cognitive functions like memory, creativity, sharpness and motivation. They’re nutrients for the brain.

Now, getting the nootropics we need just from our diet can be close to impossible. That’s why we made it our mission to combine the best nootropics available into a single brain health supplement, where all the ingredients work together synergistically. Not all brain supplements are formulated the same, and we created the best supplement to keep your mind sharp and boost your brainpower.

CogniBiotics

But it’s not only the best probiotic strains that’s behind the brain-boosting power of this product. It also contains:

  • The Chaihu Shugan San herb blend, used for over 2,200 years in Chinese traditional medicine to enhance brain health, focus and happiness levels through the gut microbiome.
  • The An Shen Bu Xin San herbal blend, an equally ancient Chinese formula traditionally used to calm the spirit, known for its cognitive performance-enhancing properties.
  • Antioxidants suitable for the brain in order to protect it from oxidative stress and “mental aging”.
  • A prebiotic complex that secures the good bacteria arrives healthy to your gut and rebalances your body’s microbiome.

This state of the art formulation is designed to:

  • Improve mood and promote a balanced stress response
  • Increase mental clarity, sharpness, enhanced memory and beat brain fog
  • Promote a better microbiome balance in the gut, which boosts a healthy gut-brain connection
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The Untold Truth About the Second Brain

We all know that probiotics are good for the body because they enhance digestion but… what does that have to do with the brain? 

The brain and the gut are intricately connected through what’s known as the Gut-Brain-Microbiome Axis1. Just like the brain, the gut contains over 30 different types of neurotransmitters.

About 90% of serotonin known as “the happiness hormone” is produced in the gut2. GABA, dopamine, acetylcholine and melatonin, among other key neurotransmitters, are also produced there. It’s no surprise the gut is often called THE SECOND BRAIN.   

And the responsible ones for generating these neurochemicals are the good bacteria living in the gut3.

That’s why probiotics are the key to a balanced microbiome that enhances mental health and performance.

But not all probiotic brain supplements are the same. That’s why for Cognibiotics, we carefully selected the 10 strains that are scientifically proven to be the most efficient at regulating the brain-gut axis. Making sure they have the resources to make it alive and healthy to the gut. 

7 Science-Proven Ways Cognibiotics Boosts Brain Health

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  • Beating Brain Fog Through Gut-Brain-Microbiome Axis

Brain fog, memory issues and concentration difficulty are easily mistaken with being absent-minded or simply lazy. The reality is they’re just symptoms of improper communication between brain cells. The responsible ones for this communication are neurotransmitters, and the bacteria balance in our gut plays a key role in the production of these4

Research has shown that an improvement in the microbiome composition can be beneficial even for people with neurological disorders5. Cognibiotics is not a substitute for medical treatment, but among all brain health supplements, it’s the best formula to Boost Brain Power

Not only because of its carefully selected probiotic strains, but also because of its ancient Chinese herbal blends that have proven to enhance the microbiome balance even further6

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  • Promotes Learning and Memory

Acetylcholine is an important neurotransmitter for learning and memory. 

P. multiflorum, S. miltiorrhiza, and R. glutinosa in Cognibiotics increase acetylcholine levels7.

Most brain supplements in the market contain ingredients that boost cognitive function, but these probiotics are like having a factory of positive neurochemicals in your own body.

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  • Balance your Stress Response

Studies show8 the probiotics L. plantarum, L. helveticus, L. fermentum, L. rhamnosus, and B. infantis promote the balance of serotonin, dopamine and GABA in the brain.

This will help you boost mood, cognitive function and a healthy stress response. We want you to be able to perform 100% when you need to put in the work! But also be able to relax and feel great with yourself when it’s time to do so.

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  • Helps your brain “stay in shape”

The brain is a muscle, and just like other muscles: If fed and exercised, it strengthens; if not, it ages and weakens.

The good bacteria9 and herbs10 in Cognibiotics work together to stimulate the production of proteins that help the brain grow, reorganize and adapt. Increasing these proteins helps with learning, memory and mood.

This makes Cognibiotics the best supplement to keep your mind sharp.

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  • Aids your brain standing the test of time.

The herbal blends in Cognibiotics also help to protect neurons against oxidative stress. 

Oxidative stress is part of our daily routine.  It comes from mental and emotional stress, environmental toxins, inflammation, unhealthy lifestyle, and more. We rarely consume enough antioxidants in our diets to withstand oxidative stress. This can contribute to brain cell damage, which translates to brain fog, fatigue, and neurologic aging.

Herbs in Cognibiotics contain antioxidants that can cross the blood-brain barrier and protect your brain from day-to-day oxidative stress11.

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  • Increases Blood Flow to the Brain

Your brain needs oxygen and vital nutrients to work well, but it’s also the organ that’s hardest to deliver blood to as it’s located at the highest point in the body and has many tiny blood vessels.

This reduced blood flow can translate to deprivation of oxygen and nutrients. This can cause fatigue, brain fog, poor cognitive function, and low mood.

The Chaihu-Shugan San herb formula normalizes brain blood flow12 in depression patients.

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  • Producing Beneficial Substances from Probiotic Metabolism

Among the benefits of probiotics is the generation of beneficial chemicals from their metabolism, known as one of the best-known postbiotics is butyrate

Low mood, brain fog, and fatigue13 are caused by sluggish neurons that can’t produce enough energy (ATP). The small fatty acids like butyrate14 can enter the brain, energize the sluggish neurons, and lower oxidative stress. 

The small fatty acids also counteract chronic inflammation15 and strengthen the gut and blood-brain barriers.16 They also promote a healthy metabolism and blood sugar levels which are important for brain health.

The Effects Of Cognibiotics Are Backed By Science,
But Also Loved By Its Users:

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Scott Taylor
Scott Taylor
Nov 22, 2020

Great Product - and it works!!

Purchased the first pot two months ago, and must say it really does exactly what it's supposed to. My gut is in better shape and my mind is certainly sharper and calmer, just what is needed in this current climate.

William M.
William M.
Jul 28, 2020

Anything by BiOptimizers is worth trying. They’re products are the best quality out there. Try Cognibiotics, it’s totally worth it!

S.L.
S.L.
Aug 24, 2020

Energized mornings.

For the last two years, I've been struggling with feeling awake in the morning before 10 am. Even with coffee or tea, I felt that I lacked energy to study and work. I've taken other probiotic blends of Lactobacillus and Bifidobacterium and most of them don't make a noticeable improvement in health. However, here's where Bioptimizers products differ. In addition to taking P3om (for several months) prior, I've been taking Cognibiotics once a day, in the morning for about 10 days, and I notice the difference in energy. I highly recommend trying Cognibiotics.

TIRED OF FEELING TIRED...

Brain fog, low mood and low performance could be standing
between you and your goals!

Work, a personal project, even investing time with our loved ones.

We all have something we want to pour mind and soul into:

But sometimes, we simply can’t. 

We postpone things, we easily get distracted, we can’t think clearly… We really want to achieve our goals but low mood just doesn’t let us.

So we then get frustrated and put our plans on hold, forgetting how capable we truly are.

We start doubting ourselves. We’re told we’re lazy- We start thinking that the challenges we face are too much for us to handle. 

Listen. You deserve a better tomorrow, and a better today. To be capable of giving your all to get where you want to be.

 And imbalance on your gut microbiome shouldn't stop you from doing it.

SO IF YOU ARE FACING:

  • Brain Fog and lack of mental clarity
  • Lack of mental sharpness, memory and learning problems
  • Constant low mood, depression and anxiety
  • Stress, irritability and mood swings
  • Low energy, boredom and mental exhaustion

It’s time to rediscover what your mind  is truly capable of with the brain-boosting power of Cognibiotics. 

TIRED OF FEELING TIRED...

Brain fog, low mood and low performance could be standing
between you and your goals!

Work, a personal project, even investing time with our loved ones.

We all have something we want to pour mind and soul into:

But sometimes, we simply can’t. 

We postpone things, we easily get distracted, we can’t think clearly… We really want to achieve our goals but low mood just doesn’t let us.

So we then get frustrated and put our plans on hold, forgetting how capable we truly are.

We start doubting ourselves. We’re told we’re lazy- We start thinking that the challenges we face are too much for us to handle. 

Listen. You deserve a better tomorrow, and a better today. To be capable of giving your all to get where you want to be.

 And imbalance on your gut microbiome shouldn't stop you from doing it.

SO IF YOU ARE FACING:

  • Brain Fog and lack of mental clarity
  • Lack of mental sharpness, memory and learning problems
  • Constant low mood, depression and anxiety
  • Stress, irritability and mood swings
  • Low energy, boredom and mental exhaustion

It’s time to rediscover what your mind  is truly capable of with the brain-boosting power of Cognibiotics. 

Still Wondering If Cognibiotics Is The Right Pick
To Exploit Your Mind’sFull Potential?

HERE'S EVERYTHING YOU NEED TO KNOW BEFORE GETTING COGNIBIOTICS

COGNIBIOTICS® QUESTIONS:

What is the recommended dosage for CogniBiotics®?

The recommended dose for CogniBiotics® can be found on the label - 2 capsules a day on an empty stomach upon waking´up.

 

However, in clinical experience, we have found the effective dose for most people is 2 capsules in the morning, 2 capsules with breakfast and 2 capsules in the evening.

If you want to start slow, take 2 capsules before breakfast and 2 capsules before dinner.

Can children take CogniBiotics®? If so, what is the recommended dosage?

CogniBiotics® is safe for children. The recommended dose is 1 capsule for every 40 lbs.

Consult your medical practitioner prior to starting any new supplement.

Can you empty the contents of the capsule in your beverage?

The contents of the capsules can be dissolved in your beverage of choice. Doing so will not improve nor diminish absorption or the health benefits you obtain.

Will CogniBiotics®, since it is a probiotic, replace P3-OM®?

No, because they contain different bacteria strains that serve different purposes. With a synergistic blend of synbiotics (pre+probiotics) and Chinese herbs, Cognibiotics® is engineered to improve mood and brain function through boosting the gut bacteria. Whereas P3OM contains the best researched strain of probiotic to boost your digestion and assimilation of proteins, along with your immune system.

What are the benefits of taking CogniBiotics®?

  • Boosts brain health and the health of the gut-brain axis
  • Promotes a balanced stress response and stress resilience
  • Promotes serotonin, dopamine and GABA balance, which is important for happy and calm mood
  • Increases acetylcholine, which is important for memory improvement
  • Reduces toxic neurotransmitter metabolites, which may cause brain fog or anxiety
  • Increases brain-derived neurotrophic factor and nerve growth factor, which are important for learning, memory, and good mood
  • Protecting neurons against oxidative stress
  • Increasing blood flow to the brain
  • Stimulating the vagus nerve, which promotes relaxation and may reduce inflammation

How many capsules in a CogniBiotics® bottle?

The CogniBiotics® bottle contains 60 capsules.

What is the shelf life of CogniBiotics®?

The shelf life for CogniBiotics® is 2 years from the manufactured date, which can be found on the bottle.

Is it okay for pregnant or breastfeeding mothers to take CogniBiotics®?

Pregnant or breastfeeding mothers should consult a medical practitioner prior to starting any new supplement, diet, or training program.

Can you multiply cultures with CogniBiotics®?

The probiotic in CogniBiotics® cannot be cultured at home because it contains other ingredients such as herbs and prebiotics.

If you’re looking to culture probiotics, we suggest using P3-OM®.

How should CogniBiotics® be stored?

Store CogniBiotics® in a cool and dry place.

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FREQUENTLY ASKED QUESTIONS:

How to Get Rid of Brain Fog?

Brain fog refers to confusion, forgetfulness, and inability to focus or think clearly. It is not a formal diagnosis but a symptom that many people struggle with, which is neither normal nor healthy. Brain fog could be a symptom of mental health issues or the beginning stages of cognitive decline, so it is important to identify the root causes and address them.

High levels of oxidative stress in the brain jams the brain mitochondria, causing your neurons to be sluggish. Lifestyle factors that elevate brain oxidative stress include:

  • Unhealthy and inflammatory diets
  • Imbalanced gut microbiome
  • Poor sleep or an unhealthy circadian rhythm
  • Stressful or traumatic life events
  • Sedentary lifestyle
  • Unhealthy gut
  • Poor blood sugar control
  • Nutrient deficiencies
  • To get rid of brain fog, these factors need to be identified and addressed. Cognibiotics can help with brain fog by improving the gut microbiome, stress resilience, and gut health.

What Is Mental Clarity?

Mental clarity is having a clear and focused mind. You can think clearly, make decisions, and deal with day to day demands without getting overwhelmed or exhausted. You’re also less likely to procrastinate and have no trouble accomplishing your tasks.

What Are the Five Best Foods for Memory?

Best foods for memory include:

  • Fatty wild ocean fish that are low in heavy metals
  • Colorful and green vegetables and fruits
  • Eggs
  • Nuts
  • Tea and coffee

What Is The Best Brain Supplement to Improve Mood?

There are multiple ways to use supplements to improve mood. For example, you can provide more neurotransmitter building blocks, such as by using 5-HTP and tryptophan to build more serotonin, or L-tyrosine to build more dopamine. St. John’s Wort is an herb that increases serotonin. You can also supply vitamins, such as vitamin B6, to promote healthy neurotransmitter production.

However, your brain works best when all your neurotransmitters are in balance. Your gut and gut bacteria affect your mood partly by influencing this balance. Some of the best brain supplements that work naturally to support your mood include:

  • Probiotics
  • Magnesium
  • Chaihu-Shugan San formula
  • Schizandra
  • Ginkgo biloba
  • Exercise
  • Meditation
  • High-quality sleep
  • Fish oil supplement
  • Eating enough choline in your diet
  • Continue to use your brain and train your memory

What are the five worst foods for memory?

  • Sugar and refined carbohydrates
  • Artificial sweeteners
  • Alcohol
  • Fish and seafood that are high in mercury
  • Vegetable oil
  • Processed foods

How can I increase my BDNF (brain derived neurotrophic factor)?

  • Exercise
  • Sun exposure
  • Infrared sauna
  • Boosting deep sleep
  • Meditation
  • Omega-3 fatty acids
  • Coffee fruit concentrate
  • Curcumin
  • Butyrate (or synbiotics)

What is the function of BDNF?

Brain-derived neurotrophic factor (BDNF) is a protein in the brain that is important for learning, memory, and mood. It stimulates the production of new brain cells and supports the connections between existing ones (synaptic plasticity).17 Exercise helps with depression by increasing BDNF levels. Also, higher BDNF improves memory, speed of learning, and makes your brain younger.

BDNF also protects the brain and helps it stay flexible (plastic) enough to adapt to new situations and even insults.

Why does my mood drop suddenly?

There are many potential reasons you could be experiencing low mood, such as:

  • A stressful or traumatic situation
  • Chronic inflammation18
  • An unhappy microbiome19
  • Compromised gut barrier and digestive problems20
  • Unstable blood sugar21
  • Imbalances of neurotransmitter22
  • Nutritional deficiencies23
  • Past concussions or traumatic brain injuries24

Many people suffer from more than one of the above. Cognibiotics can often help balance the microbiome, neurotransmitters, and the immune system, which can naturally lift your mood. However, since there could be other contributing factors, you should also work with your physician and the appropriate mental health care provider.

What is the gut brain connection?

The gut-brain-microbiome axis describes the intimate 2-way connections between your gut, your brain, and your gut microbiome. This might explain why people sometimes say they have a gut feeling or that they feel sick to their stomach.

There are numerous ways these connections happen, such as:

  • Stress can throw off the microbiome25
  • Substances produced by your microbiome can change your mood, cognitive function, or even cravings26
  • The bacteria can stimulate the vagus nerve, which may reduce overall inflammation or affect your mood 27 28
  • Gut bacteria can cause or suppress inflammation, which also affects digestive and brain health29

How do I fix my gut brain connection?

There are multiple entry points to fixing your gut-brain-microbiome axis. First, to improve your brain health, it is important to eat a healthy diet, get good quality sleep, manage your stress, and exercise. Taking probiotics alone often helps, but typically does not replace diet and lifestyle factors. Also, most probiotic strains are transient and don’t result in permanent shifts in the gut microbiome, which may be required for long-lasting shifts in brain function.

Cognibiotics is a great way to supercharge your gut-brain axis because it is much more than a probiotics. First, the combination of bacteria strains and prebiotics have been shown to synergistically boost mood and brain function.30 The 17 herbs in the formula target the brain, the gut, and the gut microbiome. The Chaihu-Shu-Gan-San formula boosts mood by improving the gut bacteria composition.31

Ready To Achieve Your Dreams With A Clear Mind?

The Benefits of CogniBiotics Probiotic Backed by Science

  • 1 Clair R. Martin, Vadim Osadchiy, Amir Kalani, Emeran A. Mayer. The Brain-Gut-Microbiome Axis. Cellular and Molecular Gastroenterology and Hepatology, Volume 6, Issue 2,2018. Pages 133-148,ISSN 2352-345X,https://doi.org/10.1016/j.jcmgh.2018.04.003.
  • 2 Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks. Filipe De Vadder, Estelle Grasset, Louise Mannerås Holm, Gérard Karsenty, Andrew J. Macpherson, Louise E. Olofsson, Fredrik Bäckhed.Proceedings of the National Academy of Sciences Jun 2018, 115 (25) 6458-6463; DOI: 10.1073/pnas.1720017115
  • 3 Kelly G. Jameson, Elaine Y. Hsiao.Linking the Gut Microbiota to a Brain Neurotransmitter.Trends in Neurosciences,Volume 41, Issue 7,2018.Pages 413-414, ISSN 0166-2236. https://doi.org/10.1016/j.tins.2018.04.001.
  • 4 Morais, L. H., Schreiber, H. L., 4th, & Mazmanian, S. K. (2020). The gut microbiota-brain axis in behaviour and brain disorders. Nature reviews. Microbiology, 10.1038/s41579-020-00460-0. Advance online publication. https://doi.org/10.1038/s41579-020-00460-0
  • 5 Cryan JF, O'Riordan KJ, Cowan CSM, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877-2013. doi:10.1152/physrev.00018.2018
  • 6 Yu M, Jia HM, Zhang T, et al. Gut Microbiota is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San. Metabolites. 2020;10(2):63. Published 2020 Feb 10. doi:10.3390/metabo10020063
  • 7 Howes MR, Fang R, Houghton PJ. Effect of Chinese Herbal Medicine on Alzheimer's Disease. Int Rev Neurobiol. 2017;135:29-56. doi:10.1016/bs.irn.2017.02.003
  • 8 Wang H, Lee IS, Braun C, Enck P. Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review. J Neurogastroenterol Motil. 2016;22(4):589-605. doi:10.5056/jnm16018
  • 9 Ohland CL, Kish L, Bell H, et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Psychoneuroendocrinology. 2013;38(9):1738-1747. doi:10.1016/j.psyneuen.2013.02.008
  • 10 Feng DD, Tang T, Lin XP, et al. Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review. Neuropsychiatr Dis Treat. 2016;12:2387-2402. Published 2016 Sep 20. doi:10.2147/NDT.S114560
  • 11 Packer L. (1995) Oxidative stress, antioxidants, aging and disease. In: Cutler R.G., Packer L., Bertram J., Mori A. (eds) Oxidative Stress and Aging. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7337-6_1
  • 12 Qiu J, Hu SY, Shi GQ, Wang SE. Changes in regional cerebral blood flow with Chaihu-Shugan-San in the treatment of major depression. Pharmacogn Mag. 2014;10(40):503-508. doi:10.4103/0973-1296.141775
  • 13 Schönfeld P, Wojtczak L. Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res. 2016;57(6):943-954. doi:10.1194/jlr.R067629
  • 14 Chambers ES, Preston T, Frost G, Morrison DJ. Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep. 2018;7(4):198-206. doi:10.1007/s13668-018-0248-8
  • 15 Braniste V, Al-Asmakh M, Kowal C, et al. The gut microbiota influences blood-brain barrier permeability in mice [published correction appears in Sci Transl Med. 2014 Dec 10;6(266):266er7. Guan, Ng Lai [corrected to Ng, Lai Guan]]. Sci Transl Med. 2014;6(263):263ra158. doi:10.1126/scitranslmed.3009759
  • 16 Puddu A, Sanguineti R, Montecucco F, Viviani GL. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm. 2014;2014:162021. doi:10.1155/2014/162021
  • 17 Miranda M, Morici JF, Zanoni MB, Bekinschtein P. Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Front Cell Neurosci. 2019;13:363. Published 2019 Aug 7. doi:10.3389/fncel.2019.00363
  • 18 Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci. 2001;933:222-234. doi:10.1111/j.1749-6632.2001.tb05827.
  • 19 Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic Review of Gut Microbiota and Major Depression. Front Psychiatry. 2019;10:34. Published 2019 Feb 11. doi:10.3389/fpsyt.2019.00034
  • 20 Moser G, Fournier C, Peter J. Intestinal microbiome-gut-brain axis and irritable bowel syndrome. Intestinale Mikrobiom-Darm-Hirn-Achse und Reizdarmsyndrom. Wien Med Wochenschr. 2018;168(3-4):62-66. doi:10.1007/s10354-017-0592-0
  • 21 Kay I. Is Your Mood Disorder a Symptom of Unstable Blood Sugar?. Sph.umich.edu. https://sph.umich.edu/pursuit/2019posts/mood-blood-sugar-kujawski.html. Published 2019. Accessed February 23, 2021.
  • 22 Nutt DJ. Relationship of neurotransmitters to the symptoms of major depressive disorder. J Clin Psychiatry. 2008;69 Suppl E1:4-7.
  • 23 Rao TS, Asha MR, Ramesh BN, Rao KS. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008;50(2):77-82. doi:10.4103/0019-5545.42391
  • 24 Rao V, Bertrand M, Rosenberg P, et al. Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2010;22(1):100-104. doi:10.1176/jnp.2010.22.1.100
  • 25 Karl JP, Hatch AM, Arcidiacono SM, et al. Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota. Front Microbiol. 2018;9:2013. Published 2018 Sep 11. doi:10.3389/fmicb.2018.02013
  • 26 Caspani G, Kennedy S, Foster JA, Swann J. Gut microbial metabolites in depression: understanding the biochemical mechanisms. Microb Cell. 2019;6(10):454-481. Published 2019 Sep 27. doi:10.15698/mic2019.10.693
  • 27 Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018;12:49. Published 2018 Feb 7. doi:10.3389/fnins.2018.00049
  • 28 Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050-16055. doi:10.1073/pnas.1102999108
  • 29 Fung TC. The microbiota-immune axis as a central mediator of gut-brain communication. Neurobiol Dis. 2020;136:104714. doi:10.1016/j.nbd.2019.104714
  • 30 Wang H, Lee IS, Braun C, Enck P. Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review. J Neurogastroenterol Motil. 2016;22(4):589-605. doi:10.5056/jnm16018
  • 31 Yu M, Jia HM, Zhang T, et al. Gut Microbiota is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San. Metabolites. 2020;10(2):63. Published 2020 Feb 10. doi:10.3390/metabo10020063