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Microbiome Breakthrough Creamy Chocolate is a powerful combination of IgYmax and synbiotics (probiotics and prebiotics), gut-healing bone broth, and collagen. It is synergistically designed to weed out suboptimal bacteria and reseed the good ones, as well as repair the gut lining.

Microbiome Breakthrough Vegetarian Vanilla is a powerful combination of IgYmax and synbiotics (probiotics and prebiotics). It is synergistically designed to weed out suboptimal bacteria and reseed the good ones, as well as repair the gut lining.

Benefits:

  • Supports a healthy gut barrier
  • Eliminates bloating & gas
  • Provides immune proteins that support gut and whole-body health
  • Promotes a healthy and balanced immune response
  • Promotes healthy zonulin levels
  • Promotes healthy nutrient absorption
  • May raise energy levels and improve well-being
  • Creamy chocolate – powder complex – 30 servings (150 grams)
  • Vegetarian vanilla – powder complex – 30 servings (150 grams)

MICROBIOME BREAKTHROUGH®

MICROBIOME BREAKTHROUGH®

MICROBIOME BREAKTHROUGH®

Best leaky gut powder supplement

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Microbiome Breakthrough
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delivered every
156 grams

Back In Stock

Due to high demand, we recently ran out of Magnesium Breakthrough but we are back in FULL STOCK. Be aware, due to extreme demand it can take 3-5 days to ship it out. We appreciate your patience and understanding.

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Microbiome Breakthrough Creamy Chocolate is a powerful combination of IgYmax and synbiotics (probiotics and prebiotics), gut-healing bone broth, and collagen. It is synergistically designed to weed out suboptimal bacteria and reseed the good ones, as well as repair the gut lining.

Microbiome Breakthrough Vegetarian Vanilla is a powerful combination of IgYmax and synbiotics (probiotics and prebiotics). It is synergistically designed to weed out suboptimal bacteria and reseed the good ones, as well as repair the gut lining.

Benefits:

  • Supports a healthy gut barrier
  • Eliminates bloating & gas
  • Provides immune proteins that support gut and whole-body health
  • Promotes a healthy and balanced immune response
  • Promotes healthy zonulin levels
  • Promotes healthy nutrient absorption
  • May raise energy levels and improve well-being
  • Creamy chocolate – powder complex – 30 servings (150 grams)
  • Vegetarian vanilla – powder complex – 30 servings (150 grams)
Frequently Bought Together

Could Leaky Gut Be
Keeping Your Health and
Performance Suboptimal?

MICROBIOME BREAKTHROUGH®

Studies show all aspects of your health and well-being are linked to your gut integrity… even if you have no digestive problems.

Most so-called “healthy” people nowadays have some degree of leaky gut, even without any official diagnosis.

Everyone is affected by modern-day leaky gut triggers, such as:

  • Gluten and other gut irritants in food
  • Stress
  • Sleep deprivation and suboptimal sleep
  • A suboptimal gut flora
  • Alcohol and processed foods high in salt, sugar, and unhealthy fats
  • Lack of fibers and plant polyphenols – the CDC says 90% of Americans don’t even get the bare minimum of fruits and vegetables daily
  • And many more
MICROBIOME BREAKTHROUGH®

In a perfect world, your gut should be able to reseal itself. Then, you go about your day with perfect health.

The problem is that our world is not perfect and most of us are constantly exposed to one leaky gut trigger or another.

These factors can increase zonulin, a protein that can open the gut barrier.

This is why leaky gut is not considered a disease… because it’s so normal to walk around feeling crummy and suboptimal all the time, like:

  • Needing coffee after lunch
  • Occasionally struggling to think or losing your train of thought mid-sentence
  • Feeling achy and discomfort
  • Feeling too lazy or sluggish to exercise or do things you enjoy
  • Sometimes struggling with gut discomfort or irregularity
  • Gaining weight as you age
  • Often feeling moody or irritable
  • Having “normal” symptoms assigned to “aging” or “hormones”
MICROBIOME BREAKTHROUGH®

The solution is NOT:

  • Coffee
  • Another glass of wine
  • Discipline
  • Diet
  • Fitness boot camp

Rather, it’s addressing your gut health at the root causes.

Microbiome Breakthrough makes a powerful gut-healing tool in your toolbox: 

  • The prebiotics feed the good bacteria, producing postbiotics that soothe the gut lining
  • The egg-based IgYmax from chicken eggs can bind to suboptimal bacteria and escort them out
  • The beneficial probiotics: L. gasseri, L. helveticus, and L. rhamnosus are strong biofilm formers that are more likely to colonize the gut

Microbiome Breakthrough®
Reduced Zonulin
Levels by Over
92.8%, Indicating a Healed and
Strengthened Gut Barrier

Dr. Gus Vickery, MD is a board-certified family physician based in Asheville, North Carolina. His practice follows the principles of functional medicine and precision medicine to address lifestyle and root causes of his patients’ complaints. These include healing the gut, identifying the ideal diet, stress management, and much more.

11 of his patients, who would be deemed healthy by conventional medicine standards, went through his gut healing program for at least 6 months. They all experienced significant improvements in health, digestion, and well-being, although their fecal zonulin levels in the Gut Zoomer Test were still elevated. 

He then introduced Microbiome Breakthrough and re-tested their zonulin levels after 3 months. To his amazement, their zonulin levels dropped to below 10% of their original levels.

MICROBIOME BREAKTHROUGH®

Average fecal zonulin concentration levels from 11 functional medicine patients, aged 34 - 71 years old (average age of 53), before and after 3 months on BIOptimizers Microbiome Breakthrough. Error bars = 1 standard deviation.

Microbiome Breakthrough is a leaky gut powder supplement. It contains:

  • A synbiotic with inulin and three powerful probiotic strains
  • IgYmax, a mixture of antibodies from chicken eggs that can bind to suboptimal microbes in the gut
  • Gut-soothing bone broth and collagen powders (for Carnivore Chocolate)

Health Benefits of Microbiome Breakthrough:

  • Provides proteins and regulating factors that support gut and whole-body health
  • Supports a balanced and robust immune response in the gut
  • Supports passive immunity in the digestive tract
  • Reduces zonulin levels
  • Promotes healthy levels of diamine oxidase enzymes produced in the gut lining
  • Overall smoother digestion and elimination
  • Some people may also find better energy levels, cognitive function, and results from their diet and workout programs. Because leaky gut manifests differently for everyone, individual responses vary

Mix one level scoop of Microbiome Breakthrough to 8 oz. of water, stir thoroughly but don’t shake or create froth. Take it once a day on an empty stomach.

Store in a cool and dry location.

Please consult a healthcare professional before beginning any new supplement, diet, or training program, or if you are undergoing treatment for a medical condition.

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Ultimate Intra-Workout Shake
Ultimate Intra-Workout Shake
What are the Benefits of Microbiome Breakthrough?

Microbiome Breakthrough is a synergistic blend designed to support a healthy gut flora and gut barrier functions.

IgYmax, a key component of LGG, has been clinically shown to reduce the leaky gut marker Zonulin by over 90%. Also, it improves the gut lining’s ability to break down histamine.

Many suboptimal bacteria in your gut won’t leave because they camp out in their “biofilms,” which protect themselves from antimicrobials and your immune cells. IgYmax can disrupt these biofilms, while the good bacteria strains in Microbiome Breakthrough are good biofilm builders. Together, both the IgYmax and good bacteria strains help reshape your gut flora and create more healthy biofilms.

The prebiotics, collagen, and gelatin in Carnivore Chocolate provide food for the good gut bacteria and nutrients that nourish the gut lining. The prebiotics improve the survival of good gut bacteria. Also, when the good bacteria ferment these nutrients, they provide beneficial and gut-healing substances such as butyrate.

When is the best time to take Microbiome Breakthrough?

Microbiome Breakthrough can be taken on an empty stomach upon waking to enjoy optimal benefits.

What is the recommended dosage for Microbiome Breakthrough?

The recommended dosage for Microbiome Breakthrough is one level scoop for one 8 oz. cup. Take it once a day on an empty stomach. You can also use more scoops of Microbiome Breakthrough in protein shakes or other recipes, as shown below.

Can children take Microbiome Breakthrough? If so, what is the suggested dosage?

Microbiome Breakthrough is not recommended for children.

How should Microbiome Breakthrough be stored?

Store Microbiome Breakthrough in a cool and dry location.

What is the shelf life for Microbiome Breakthrough?

The shelf life for Microbiome Breakthrough is 2 years from the manufactured date, which can be found on the bottle.

Is it okay for pregnant or breastfeeding mothers to take Microbiome Breakthrough?

Pregnant or breastfeeding mothers should consult a healthcare professional before beginning any new supplement, diet, or training program, or if they are undergoing treatment for a medical condition.

MICROBIOME BREAKTHROUGH®
MICROBIOME BREAKTHROUGH®
  • Made in USA
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.5 inches
  • Bottom diameter: 2 inches
  • Height: 4.5 inches
  • Weight: 3.6 ounces

Caution:

Do not use if ulcer or gastritis are present.

MICROBIOME BREAKTHROUGH
MICROBIOME BREAKTHROUGH
MICROBIOME BREAKTHROUGH
MICROBIOME BREAKTHROUGH
MICROBIOME BREAKTHROUGH
MICROBIOME BREAKTHROUGH

MICROBIOME BREAKTHROUGH® - 365-Day Money Back Guarantee

All BIOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BIOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we'll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

365 Money-Back Guarantee

Why BIOptimizers Is A Different Kind Of Company

  • "BEST IN CLASS" guarantee: Our mission is focused on customer obsession. If after trying our products you don't feel we are the BEST IN CLASS, we will refund your money.
  • We work with 5 world-class formulators to create the best in class formulas
  • Customers love us: 5000+ positive product reviews
  • 99.3% customer satisfaction
  • We have helped over 662,794 legendary customers optimize their health since 2004
  • The 365 Day “Best Product Ever Or Your Money Back” Guarantee
  • One of the fastest growing companies in the USA - 2 years in a row
  • Experienced customer service: our happy health concierges are happy to help via phone at (800) 719-2467 or email [email protected]

BIOptimizers Was Born From Pain And Passion

Wade’s passion and mission for helping others optimize their health started when he witnessed his 23-year-old sister pass away from cancer. It was a heart-breaking experience that shaped his destiny. That’s when he realized that health was the most precious asset we have in this life.

Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months. He watched his friend’s entire life transform as a result. He went from never having a girlfriend to being married in just a couple of years.

Wade Lightheart

Wade Lightheart

President

Matt Gallant

Matt Gallant

Chief Executive Officer

Wade and Matt were both trainers working with pro athletes and other high performers. They both spent a decade in the gym helping people transform their health. Wade and Matt met in the gym, struck a friendship, and then started a business partnership that has been going strong since 2004.

That’s right, we started selling fitness programs, digestive enzymes and organic plant-based protein in 2004. Our obsession to build the best-in-class formulas and solutions just gets stronger. Our policy is, “If we can’t build the best product in that category, forget about it.”

We’re willing to go ALL IN on the formulas. What does this mean? Our average cost per bottle is 200% to 400% higher than most of our competitors. We use the optimal, effective doses of the most researched ingredients. We know that once you experience the results, you’ll be a fan of BIOptimizers for life.

Matt & Wade Matt & Wade
Matt & Wade Matt & Wade
BIOptimizers-2022Inc5000

Thank YOU for helping us become one of the fastest-growing companies in America - 2 Years in a row.

Thank you for trusting us with your health.

matt-gallant

CEO/Co-founder of BIOptimizers

Scientific Studies
  1. “Chelated Magnesium Uses, Side Effects & Warnings.” Drugs.com, www.drugs.com/mtm/chelated-magnesium.html.
  2. Schutten, Joëlle C., et al. “Effects of Magnesium Citrate, Magnesium Oxide and Magnesium Sulfate Supplementation on Arterial Stiffness in Healthy Overweight Individuals: A Study Protocol for a Randomized Controlled Trial.” Trials, vol. 20, no. 1, 28 May 2019, https://doi.org/10.1186/s13063-019-3414-4.
  3. “Magnesium Glycinate Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD.” Www.webmd.com, www.webmd.com/drugs/2/drug-152090/magnesium-glycinate-oral/details.
  4. Uysal N, Kizildag S, Yuce Z, Guvendi G, Kandis S, Koc B, Karakilic A, Camsari UM, Ates M.Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019 Jan;187(1):128-136. doi: 10.1007/s12011-018-1351-9. Epub 2018 Apr 21. PMID: 29679349.
  5. Maypro. “Sucrosomial® Magnesium.” Maypro, www.maypro.com/products/sucrosomial-magnesium-a-source-of-magnesium-oxide-with-superior-bioavailability.
  6. McCarty MF. Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate. Med Hypotheses. 1996 Feb;46(2):89-100. doi: 10.1016/s0306-9877(96)90007-9. PMID: 8692051.
  7. Rosenfeldt FL. Metabolic supplementation with orotic acid and magnesium orotate. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:147-52. doi: 10.1023/a:1007732131887. PMID: 9794088.
  8. de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
  9. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
  10. Grases G, Pérez-Castelló JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006;19(2):102-106.
  11. Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411
  12. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  13. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  14. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
  15. Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L. Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine. Magnes Trace Elem. 1990;9(5):272-278.
  16. Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262.
  17. Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187(1):128-136. doi:10.1007/s12011-018-1351-9
  18. DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775
  19. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  20. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
  21. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047
  22. Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067
  23. Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661
  24. Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223.
  25. Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7
  26. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136.
  27. Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855
  28. Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498
  29. Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance?. Nutrients. 2017;9(9):946. Published 2017 Aug 28. doi:10.3390/nu9090946
  30. Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927
  31. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
  32. Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022
  33. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664
  34. Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994
  35. Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742
  36. Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
  37. Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.
  38. Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538
  39. Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.