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What supplements should I take to lose weight?

Last Updated On September 23, 2021

This is the time of year when many of us are considering getting back to the gym and picking up more healthy habits. Among these, weight loss is a common health goal, so questions about weight loss supplements often come up.  In this article, we’ll discuss the different supplement categories that can support your weight…

Reviewed by Adna Goralija
Fact checked by Nattha Wannissorn

This is the time of year when many of us are considering getting back to the gym and picking up more healthy habits. Among these, weight loss is a common health goal, so questions about weight loss supplements often come up. 

In this article, we’ll discuss the different supplement categories that can support your weight loss goals. Some of these can help with weight loss by supporting hormone balance while others correct nutrient deficiencies, so you can continue using them after you’ve reached your goals. 

Keep in mind that no dietary supplement can bypass the need for a caloric deficit through diet and exercise for weight loss.

Blood sugar balancing supplements

supplement pills

Many people who carry extra weight, especially around the midsection, struggle with insulin resistance. Insulin resistance can also contribute to excessive hunger and sugar cravings. Therefore, restoring insulin sensitivity, especially in the muscles, can help with fat loss. For this reason, supplements that support healthy blood sugar levels may help with weight loss. 

Insulin is a hormone that takes glucose from the blood and into the cells for energy. High blood glucose levels can damage certain insulin receptors, such as Glut4, in muscle cells, making them unable to take up glucose. This unmetabolized glucose remains in the blood or travels to the liver or fat cells where it will be converted to fat. This results in weight gain.

Better insulin sensitivity results in more glucose being used by muscle cells rather than being converted into fats. This can support healthy body composition.

Mitochondria are the cells’ “energy factories”. Some blood sugar balancing supplements increase a process known as mitochondrial uncoupling (production of heat). The uncoupling of mitochondria can increase energy expenditure and thus help with weight loss.

If you are struggling with weight loss, even though you are dieting and exercising, then it is time to try Blood Sugar Breakthrough. This supplement contains chromium which has been shown to regulate carbohydrate and fat metabolism, increase lean body mass, and accelerate weight loss.


Synbiotics are supplements that combine a mixture of probiotics and prebiotics. In the gut, these work to improve the activity and survival of “good” microorganisms. They thereby promote a healthy gut microbiome.

Metabolic endotoxemia is the presence of endotoxins in the blood. These endotoxins are lipopolysaccharides (LPS) and their presence in low levels is normal. However, at higher levels, these LPS can stimulate low-grade inflammation. Endotoxemia induced by a fat-rich dietcan contribute to many problems, one being obesity.

So, let’s look at how synbiotics and endotoxemia are linked. 

Obese people have gut microbiomes that have a decreased bacteria diversity.This imbalance in the gut is called dysbiosis. Dysbiosis as a result of a high-fat diet is a potential cause of metabolic endotoxemia. 

Furthermore, endotoxemia causes the walls of the intestines to become “leaky”. This allows bacteria and toxins to pass through into the bloodstream, setting up inflammation and other problems.

Synbiotics can help rebalance the gut bacteria and reseal the leaky gut.

Butyrate is a fatty acid that is produced when microbes in our gut ferment dietary fibers. It has anti-oxidant and anti-inflammatory properties. Therefore, it can reduce LPS by inhibiting the inflammatory response.

Furthermore, butyrate possesses some metabolic effects, one of them being the prevention of metabolic endotoxemia.

This is all good news that shows how introducing synbiotics into your diet and exercise regime can “get rid of” metabolic endotoxemia by eliminating dysbiosis and leaky gut, thus helping with weight loss. 

Leaky Gut Guardian is a perfect and powerful combination of IgYmax and synbiotics that helps with balancing your gut microbiota and reducing intestinal permeability. 


measuring tape and pills

Magnesium is an essential mineral that is involved in over 300 metabolic reactions in our body, including energy production.

Magnesium deficiency has been linked to a wide range of human diseases: cardiovascular disease, obesity and insulin resistance, bone disorders, lung issues, and mental illnesses.

A diet rich in magnesium is associated with a lower risk of diabetes and insulin resistance, due to magnesium’s role in glucose metabolism. Supplementation with magnesium benefited individuals that were overweight by improving their insulin sensitivity.

Further studies proposed that obese and overweight individuals have low levels of magnesium in their blood. 

Since it is difficult to get the required dose of magnesium through diet alone, using magnesium supplements will ensure you get enough and will help regulate glucose metabolism, thus helping with weight loss. 

Vitamin D

Most of us know that vitamin D is important when it comes to bone health. However, vitamin D also plays a role in various other body processes.

For example, low levels of vitamin D are associated with obesity, insulin resistance, diabetes, and cardiovascular diseases.

Obese people often have significantly lower blood levels of vitamin D than individuals who are not obese. A possible cause is that fat tissue increases the clearance and uptake of vitamin D.

In one randomized study, 218 overweight women were put on a weight loss program. Half of them received vitamin D supplementation with this program, and the other half were given a placebo. The women who were given vitamin D showed a greater improvement in weight loss. 

Furthermore, overweight women who were given vitamin D for 12 weeks showed a decrease in body fat. However, they did not lose weight. 

The conclusion is that vitamin D supplements can promote fat loss as long as a healthy diet and exercise are included. 

Fat burners

plate burn fat

Fat burners are typically non-nutritive supplements that:

  • increase energy expenditure 
  • increase weight loss
  • are involved in fat metabolism 
  • aid in fat oxidation during exercise


7-keto-DHEA is a hormone produced by the adrenal glands. This hormone assists with the burning of calories to produce body heat. Due to this property, 7-keto was seen as a potential supplement for weight loss.

30 individuals were put on an 8-week weight loss program: half of them received 7-keto and the other half a placebo. Individuals that received 7-keto lost significantly more weight (2.88 kg) than the placebo group (0.97 kg).

Furthermore, in another study, taking 7-keto increased the participants’ metabolism by 1.4%.

7-keto is a “fat burner” supplement that improves your metabolism and aids in weight loss, as long as it is followed by a healthy diet and exercise. 


Innoslim is a natural fat burner made of extracts from Panax notoginseng and Astragalus membranaceus. It reduces fat by improving the metabolic environment. These supplements decrease the body’s absorption of glucose in the intestines by reducing an important glucose transporter called SGLT1. It then increases glucose absorption in muscle cells through increased glucose transport protein GLUT4.

These effects decrease the blood glucose levels and fat build-up in your body.

InnoSlim helps to lower blood sugar, lipids, and body fat. It may also help to reduce insulin resistance and inflammation. This may result in weight loss as well as lower blood sugar and insulin levels.

Appetite suppressants

Appetite suppressants are supplements and/or food that make you feel full, helping you to eat less.


Hoodia is a succulent plant long used by tribal people in Southern Africa as an appetite suppressant. 

The evidence is scarce and studies have mostly been done on rats, but hoodia seems to target both fat and muscle tissue to achieve weight loss. It works by tricking the brain into thinking you’ve eaten enough. Overweight individuals who ate hoodia showed greater improvement in weight loss than individuals who were given a placebo.


Fenugreek is a herb that is used as a weight-loss tool. It works as an appetite suppressant by causing those who take it to consume less fat and, therefore, fewer calories.

In a 6-week study, repeated administration of a fenugreek seed extract reduced the amount of fat healthy but overweight subjects ate by a small but substantial amount. Furthermore, it increased their feeling of fullness.

Bitter melon

bitter melon

Bitter melon is a vine plant that is famous for its many beneficial properties. One of those properties is that it can reduce weight gain and insulin resistance. 

In our bodies, bitter melon may boost the activity of proteins and certain receptors responsible for glucose regulation, while decreasing the production of fat in adipose tissues and increasing fat breakdown.

Furthermore, bitter melon can suppress leptin – a hormone that helps the body maintain its weight. 

Garcinia cambogia

Garcinia cambogia is a yellowish fruit that contains hydroxycitric acid, an ingredient that is beneficial for weight loss. 

It works by either reducing appetite or blocking fat production in fat cells. 


Coffee is almost everyone’s favorite warm beverage, especially in the morning when we need that boost of energy to kick start our day.  

Scientists have been exploring the correlation between drinking coffee and weight loss. A meta-analysis showed that higher coffee intake is associated with lower BMI and waist circumference.

Furthermore, in another meta-analysis, higher coffee intake correlated with a reduction in weight, BMI, and body fat. 

Bottom line

Many supplements can promote and aid weight loss. Their mode of action ranges from increasing insulin sensitivity to blocking fat production in fat cells. These supplements not only aid in weight loss but can also have other beneficial effects on the body. 

For instance, magnesium also improves the quality and quantity of sleep, vitamin D is good for our bones, while synbiotics help with gastrointestinal problems such as bloating. 

Losing weight can be very difficult, especially around areas of the body where stubborn fat accumulates. Using supplements such as fat burners, appetite suppressants, and natural supplements can help you achieve your weight loss goals and improve your overall health. 

We promise you that you will improve your performance and results by incorporating these supplements into your healthy diet and exercise regime.

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