Trending

Berberine Breakthrough

Name: Berberine Breakthrough
Brand: BiOptimizers
SKU: 2680-BSBFSV2B
Price: 38.99 USD
Availability: InStock

Features GlucoVantage® — Up to 5X Better Absorption Than Standard Berberine [22]

$38.99

Earn $0.39 BIObucks on every order

60 capsules

FREE SHIPPING 1

Recommended By Top Health Experts & Performers

Elizabeth Skordinski

Weight loss creator, founder of Countess of Shopping, BIO Ambassador

"BIOptimizers products are exceptional and have changed my health in so many ways. I am so grateful for BIOptimizers!"

Dr. Christian Gonzalez

BIO Ambassador

“There’s an abundance of research behind Berberine showing that it’s effective for regulating blood sugar. Berberine Breakthrough by BIOptimizers is my favorite product. It's an incredible formula and they’re an incredible company. “

Crosby Taylor

BIO Ambassador

"Thanks for sending the Berberine! I have been using it everyday and totally forgot how magical this product is. I've also not been training. Even with this the Berberine has been truly remarkable."

Paul Chek

Founder of the CHEK Institute, Spirit Gym podcast host, BIO Ambassador

"I love BIOptimizers products. You can tell the high quality ingredients in each product giving maximum results. Their high standards for ingredients show in each product."

Real Reviews From Our Community

Actually fantastic. I monitor my blood glucose and when I started taking this over average berberine, I noticed a difference after meals. I highly recommend this.

Zach Henderson
I love Berberine Breakthrough
I don't have a lot of sugar but when I do I love knowing I have this product.

Anna C.
I’ve been taking Berberine Breakthrough alongside MassZymes and Gluten Guardian. I feel more energised.

Fernanda S.

Why Berberine Breakthrough is Better

Everyone's Talking About Berberine

Scroll social media or tune into a health podcast, and you’ll hear about berberine. Interest has grown because emerging research suggests berberine may support healthy blood sugar levels already within the normal range and overall metabolic wellness when used consistently.*

But Here’s What You Might Not Know

Many standard berberine supplements are limited by poor absorption. This means a large portion may pass through the body before it can be fully utilized—making it harder to experience its potential benefits.*

We Solved the Absorption Problem

Berberine Breakthrough features GlucoVantage®- a unique dihydroberberine form that has been shown in early studies to be 5X more bioavailable than regular berberine. That means better absorption and more efficient support for your metabolic health.

Formulated for Comprehensive Support

We didn’t stop at absorption. While many formulas rely on berberine alone, our team applied rigorous formulation and testing standards to create a more complete approach.

Berberine Breakthrough includes GlucoVantage® for enhanced absorption, plus Cinnulin PF™, R-Alpha Lipoic Acid, and additional research-backed ingredients—each selected to support metabolic health and overall wellness.*

This Is What Next-Level Berberine Looks Like

Supports Metabolic Balance

When your metabolism is supported, everything feels more balanced. This formula helps support healthy glucose metabolism and overall metabolic function—so you can feel more like yourself.*
Everyday Energy Support

Steady glucose availability supports consistent daily energy. This formula helps maintain healthy blood sugar levels already within the normal range to support steady energy throughout the day.*
Supports You As You Age

Metabolic and antioxidant support work together to help support vitality and resilience over time—aging support you can feel good about.*
Supports Consistent Energy Levels

Helps maintain healthy blood sugar levels already within the normal range, supporting more even energy and fewer mid-day dips.*

Berberine breakthrough ingredient blend vs. other products

INGREDIENT

Glucovantage™ (Dihydroberberine)

Cinnulin PF™ (Cinnamon Extract)

Alpha-Lipholic Acid

Benfiotiamine

InnoSlim®

Gymnema Extract

Bitter Melon

Fucoxanthin

Sea Buckthorn

*Comparison based on label-declared ingredients. No claims are made regarding relative efficiacy or health outcomes.

YOUR DAILY METABOLISM BREAKTHROUGH IS HERE

Supports the way your body uses carbs and fat, and responds to real-world eating to support healthy blood sugar levels, without harsh stimulants.

Ingredients:

GLUCOVANTAGE™ (DIHYDROBERBERINE)
GlucoVantage™ (Dihydroberberine) absorbs up to 5X better than regular berberine and supports healthy blood sugar, fat metabolism, and overall metabolic function.*

CINNULIN PF™
A cinnamon extract that supports blood sugar balance and metabolic function*

INNOSLIM™
Helps the body process glucose from food.*

FUCOXANTHIN
Encourages healthy fat distribution

CYANTHOX™
Supports healthy aging*

365-DAY MONEY BACK GUARANTEE

All BIOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BIOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we'll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

Product Information

Product Dimensions

Cap diameter: 1.58 inches
Bottom diameter: 1.95 inches
Height: 3.78 inches
Weight: 1.98 ounces

CAUTION:

Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you’re undergoing treatment of a medical condition.

Find Out More

Crush Your Cravings

Get Your Berberine Breakthrough

Scientific Studies

Wang C, Wang Y, Ma SR, et al. Berberine inhibits adipocyte differentiation, proliferation and adiposity through down-regulating galectin-3. Sci Rep. 2019;9(1):13415. Published 2019 Sep 16. doi:10.1038/s41598-019-50103-5
Karsono AH, Tandrasasmita OM, Tjandrawinata RR. Bioactive fraction from Lagerstroemia speciosa leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis. J Exp Pharmacol. 2019;11:39-51. Published 2019 May 2. doi:10.2147/JEP.S181642
Lee SG, Siaw JA, Kang HW. Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation. Foods. 2016;5(4):83. Published 2016 Dec 6. doi:10.3390/foods5040083
Zakerkish M, Jenabi M, Zaeemzadeh N, Hemmati AA, Neisi N. The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial. Sci Rep. 2019 May 13;9(1):7289. doi: 10.1038/s41598-019-43838-8. PMID: 31086222; PMCID: PMC6514000.
Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi:10.1155/2015/496169
Kim J, Yang G, Kim Y, Kim J, Ha J. AMPK activators: mechanisms of action and physiological activities. Exp Mol Med. 2016;48(4):e224. Published 2016 Apr 1. doi:10.1038/emm.2016.16
Lowry, F., 2012. Hot Flashes Linked to Resistance. [online] Medscape.[Accessed 6 April 2021].
Raichle ME, Gusnard DA. Appraising the brain's energy budget. Proc Natl Acad Sci U S A. 2002;99(16):10237-10239. doi:10.1073/pnas.172399499
Ríos JL, Francini F, Schinella GR. Natural Products for the Treatment of Type 2 Diabetes Mellitus. Planta Med. 2015;81(12-13):975-994. doi:10.1055/s-0035-1546131
Wang CW, Su SC, Huang SF, et al. An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression.Mol Pharmacol. 2015;88(6):1072-1083. doi:10.1124/mol.114.097352
Hui H, Tang G, Go VL. Hypoglycemic herbs and their action mechanisms. Chin Med. 2009;4:11. Published 2009 Jun 12. doi:10.1186/1749-8546-4-11
Hlebowicz J, Hlebowicz A, Lindstedt S, et al. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, glucose-dependent polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009;89(3):815-821. doi:10.3945/ajcn.2008.26807
Gao S, Guo Q, Qin C, Shang R, Zhang Z. Sea Buckthorn Fruit Oil Extract Alleviates Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Cells and Rats. J Agric Food Chem. 2017;65(7):1328-1336. doi:10.1021/acs.jafc.6b04682
Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi:10.1155/2015/496169
Zhao J, Zhou H, An Y, Shen K, Yu L. Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound. Oncol Lett. 2021;21(2):84. doi:10.3892/ol.2020.12345
Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ. Improved Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors. PPAR Res. 2008;2008:581348. doi:10.1155/2008/581348
Pershadsingh HA. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert Opin Investig Drugs. 2007;16(3):291-302. doi:10.1517/13543784.16.3.291
Chao CY, Huang CJ. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci. 2003;10(6 Pt 2):782-791. doi:10.1159/000073966
Beekmann K, Rubió L, de Haan LH, et al. The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ). Food Funct. 2015;6(4):1098-1107. doi:10.1039/c5fo00076a
Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi:10.1155/2015/496169
Maeda H. Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: a review. J Oleo Sci. 2015;64(2):125-132. doi:10.5650/jos.ess14226
Moon, J. M., Ratliff, K. M., Hagele, A. M., Stecker, R. A., Mumford, P. W., & Kerksick, C. M. (2021). Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial. Nutrients, 14(1), 124.

*These statements have not been evaluated by the Food and Drug Administration. Probiotic supplements are not drugs and therefore are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Your Cart