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  • Increase your absorption of key amino acids & certain vitamins
  • Experience better digestion & gut health
  • Increase your energy levels
  • Enhance your mental clarity and focus



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60 capsules

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Due to high demand, we recently ran out of Magnesium Breakthrough but we are back in FULL STOCK. Be aware, due to extreme demand it can take 3-5 days to ship it out. We appreciate your patience and understanding.

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  • Experience faster muscle recovery
  • Contains 100,000 units of protein-digesting enzymes per capsule
  • Vegetarian-friendly, vegan-friendly, dairy-free, and soy-free
  • Increase your absorption of key amino acids & certain vitamins
  • Experience better digestion & gut health
  • Increase your energy levels
  • Enhance your mental clarity and focus
  • Experience faster muscle recovery
  • Contains 100,000 units of protein-digesting enzymes per capsule
  • Vegetarian-friendly, vegan-friendly, dairy-free, and soy-free
Frequently Bought Together


Informed Sports Logo

Informed Sport is a global sports supplement quality assurance and supplement certification program. The presence of the Informed Sport supplement certification on the packaging of a product assures athletes and consumers that:

  • Every batch of a product has been tested for 250+ substances that are prohibited in sports
  • Every product was made in an environment with quality systems appropriate for sports nutrition manufacturing

Get Your Best Digestive Enzymes To The Optimal Zone

Get Your Enzymes To The Optimal Zone

Why MassZymes is the best full spectrum digestive enzymes supplement on the planet:

  • 100% plant-based, naturally-derived best digestive enzymes blend
  • Contains high concentration of the best digestive enzymes that are active at a variety of acidity levels, which ensures optimal digestion throughout the entire digestive tract
  • Highly concentrated with the best digestive enzymes that digest proteins, starches, sugars, fibers, and fats
  • Maximize digestion and nutrient absorption
  • Relieves indigestion, gas, bloating, and fatigue after meals
  • Contains both digestive and systemic protein-digesting enzymes
  • Take with meals to enhance digestion and nutrient absorption
  • Take on an empty stomach for systemic enzyme benefits
  • 100% Satisfaction guarantee with respect to quality, purity, potency, and effectiveness
  • Produced in small batches with medical-grade ingredients
  • Improve exercise recovery and tissue remodeling, which is important for wound healing and skin rejuvenation
  • Incomplete protein digestion can result in food fragments that can cause food allergies or sensitivities. MassZymes is designed to maximize protein digestion and minimize inflammation from food.


Vitamin D3, Protease / Peptidase Blend (Protease - neutral/alkaline protease for vegetable proteins), Protease, Peptidase), Enzyme Blend (Fungal Amylase, Bromelain, Aplha Galactosidase, Glucoamylase, Lactase, Fungal Lipase, Lipase (Yeast), Lipase (Food Grade); Lipase, Invertase, Phytase, Pectinase, Hemicellulase, Cellulase, Beta Glucanase

Other Ingredients: Rice flour, Hypromellose (capsule), Organic Rice Fiber.

Full Spectrum Digestive Enzymes Benefits

  1. Full Spectrum Digestive Enzymes Optimize Digestive Function

    Due to aging and a stressful lifestyle, most people have suboptimal digestive function, which can lead to subclinical nutrient deficiencies and digestive problems. MassZymes contains the best digestive enzymes that are active at a variety of acidities offering digestive support throughout the gut. It also contains digestive enzymes that specifically break down fibers and sugars that are hard to digest. Therefore, MassZymes can help relieve indigestion, gas, bloating, and other symptoms of poor digestion.

  2. Systemic Enzymes Promote Exercise Recovery And Balanced Immune Response

    MassZymes contain plant-based, systemic protein-digesting enzymes that can get absorbed into the bloodstream. These full spectrum digestive enzymes can break down debris from the wound healing processes. They also support cell growth and collagen production.

    Recovery from exercise typically involves wound healing processes, so systemic enzymes can support exercise recovery and reduce exercise-induced soreness. In healthy active adults, systemic enzyme therapy before and after exhaustive exercise improved strength gains and reduced lab markers of inflammation.

  3. Improves Overall Energy Levels

    The less optimal your digestion, the more energy your body requires to properly digest food, which may leave you experiencing a slump in energy after meals. Also, suboptimal digestion allows incompletely digested foods to trigger your immune system, leading to inflammation that can rob you of your energy. Lastly, nutrient deficiencies such as low iron and vitamin B12 can often lead to perpetual fatigue.

    By providing your body with systemic full spectrum digestive enzymes, you relieve your body of the energetic burden in the digestive process. MassZymes can help ensure that your food is completely digested and nutrients maximally absorbed. As a result, many MassZymes users experience improved energy levels

  4. Helps With Leaky Gut And Food Sensitivities

    Insufficient digestive enzymes from the pancreas, combined with leaky gut, can increase systemic inflammation. The leaky gut can expose the contents inside the gut, such as food and bacterial toxins, to your immune system. As a result, you may develop food sensitivities or allergies.

    Having bacterial toxins in the bloodstream can cause chronic low-grade inflammation that causes obesity, brain fog, and depression.

    A full spectrum digestive enzyme blend like MassZymes can help restore the digestive capacity and support gut barrier health. Some of our customers experience major relief and reduction in food sensitivities. However, individual responses vary—others may need additional changes in their diet, lifestyle, and supplements such as Leaky Gut Guardian and P3OM to achieve the same relief. Keep in mind that MassZymes is not approved to treat or prevent any diseases.

  5. Promotes A Lean And Toned Physique In Combination With The Right Diet And Exercise

    Full spectrum digestive enzymes are not fat burners, so they don’t directly help with weight loss. However, there are a few ways that full spectrum digestive enzymes like MassZymes may promote a lean and toned physique:

    • By improving your energy levels and making it easier to become more active
    • By improving your nutrification, so you feel more satiated and need less food
    • By reducing systemic inflammation that increases hunger and cravings, while reducing your energy
    • By improving your exercise recovery so you see better results from your workout and can train harder at your next session
    • By correcting nutrient deficiencies that may slow down your metabolism
  6. Improves The Absorption Of Minerals, Such As Iron And Magnesium

    Mineral deficiencies are so common these days because our soils are depleted and digestion is suboptimal. Also, anti-nutrients such as phytates in grains and legumes can capture these minerals and make them unabsorbable.

    MassZymes is a full spectrum digestive enzymes supplement that contains phytase, which helps break down phytates, allowing minerals from your foods to be more readily absorbed. Some of our users find that it helps them restore healthy iron levels.

  7. Improves Skin Health

    Your skin shows how well your entire body and digestive system are functioning. Many people notice that certain foods trigger breakouts due to increased inflammation, or that some nutrient deficiencies cause dull or aging skin. By supporting your gut barrier and supporting optimal digestive health, MassZymes can help improve your skin health.

    The anti-aging skin repair process depends heavily on your body’s wound healing capacity. The systemic enzymes in MassZymes may slow down skin aging and support healthy skin repair.

How Full Spectrum Digestive Enzymes Work?

Full spectrum digestive enzymes help catalyze numerous biochemical reactions in your body. With aging and stress, we deplete the reserves of our own digestive enzymes, which leads to nutrient deficiencies, fatigue, weight gain, and poor skin health.

MassZymes is a 100% plant-based highly concentrated full spectrum digestive enzymes supplement. It contains the best digestive enzymes that are active at a variety of pH levels in order to fully support your digestion throughout your digestive tract.

When To Take a Full Spectrum Digestive Enzyme Supplement

To get digestive benefits, such as reduced bloating, indigestion, and post-meal fatigue, take digestive enzymes with meals. To reap systemic benefits of plant proteases, such as improved exercise recovery, breaking down inflammatory proteins and scar tissues, and wound healing, take a digestive enzyme supplement on an empty stomach.

Plant proteases can provide both digestive and systemic benefits, and we would recommend adjusting the timing of your intake based on your goals. You can also take it both with and without meals, even on the same day. However, you should take it with food if taking supplements on an empty stomach causes upset digestion.

Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition.

Ultimate Digestive Solution
Ultimate Digestive Solution
High Protein Meal
High Protein Meal
Muscle Building High Calorie Stack
Muscle Building High Calorie Stack
Optimizing Your Fasting
Optimizing Your Fasting
The Perfect Meal
The Perfect Meal
Ultimate Intra-Workout Shake
Ultimate Intra-Workout Shake
Ultimate Biological Optimization Program
Ultimate Biological Optimization Program

MassZymes Questions:

When is the best time to take MassZymes?

Systemic enzymes are taken on an empty stomach as digestion will interfere with their effectiveness. We suggest you take our MassZymes first thing in the morning on an empty stomach, or during the day to elicit a systemic enzymatic effect. To support a healthy digestion, take MassZymes a few minutes before each meal of the day.

**Please Note: Our enzymes can be used both for food digestion and on an empty stomach.

When you take our MassZymes on an empty stomach, the enzymes don’t get tied up with digesting food. Rather, studies have shown that the protein-digesting enzymes can get absorbed whole and deliver health benefits throughout the body. By providing your gut with the supplemental enzymes, you free up the gut cells from the demands of needing to produce so many of its own digestive enzymes. So, the gut lining and organs that produce enzymes have more amino acids and energy for metabolism and restorative processes. Your pancreas produces and secretes many different digestive enzymes, so taking MassZymes can be a way to support your pancreas.

Are enzymes dangerous?

If you’ve eaten raw or fermented foods, you’ve eaten digestive enzymes. Also, digestive enzyme supplements have been around for nearly 100 years, some of them approved as medications. Digestive enzymes are very safe to take because they are very similar to the enzymes, acid, and bile that are naturally secreted into your gut. Your gut lining cells have inherent mechanisms that protect themselves from being digested.

If you have gastritis or ulcers, it may not be a good idea to take digestive enzymes. Also, some enzymes may interact with blood-thinning medications. Be sure to consult your health professional on whether enzymes are safe for you to use, especially if you are on medications.

Are all enzymes created equal?

Absolutely not! There are many digestive enzyme combination supplements out there. Some enzyme supplements are for digestive support, while others are systemic, to be absorbed into the bloodstream to reduce inflammation and support wound healing. Each enzyme in the combination works in a narrow range of pH (acidity and alkalinity). Your stomach is very acidic, whereas your small intestine is very alkaline. Most enzyme supplements only contain enzymes that work best either in the stomach or the small intestine, but not both. They also contain much lower doses of active enzymes to deliver real digestive benefits.

Through in vitro testing, we know that MassZymes work in a full range of pH to maximize the digestive benefits.

MassZymes contains a higher concentration of proteases (protein-digesting) enzymes than any other enzyme supplement on the market. These proteases can help maximize your protein absorption. Also, when taken on an empty stomach, the systemic proteases can get absorbed into the bloodstream to support the immune system, tissue repair, and exercise recovery. A clinical study showed that a protease supplement containing Proteases 4.5 and 6.0 can improve strength loss and support short-term exercise recovery compared to placebo.

Why do you use RICE BRAN in this product?

In studies, rice bran was effective in retaining the nutrients in enzymatic processes and can improve nutritional value and health benefits in supplements.

Enzymes can become activated by moisture. By including a stabilized hypoallergenic rice bran we are able to offer longer shelf life and improved effectiveness of the product.

Does MassZymes (Best Digestive Enzymes) only digest protein?

Digestive enzymes help break down the food you consume by speeding up chemical reactions converting nutrients into substances your body can absorb.

We use different types of enzymes to target different nutrients:

  • Protease in our enzymes breaks down protein
  • Amylase in our enzymes breaks down carbohydrates and sugars
  • Lipase breaks down fats in our body
Is MassZymes vegan and cruelty-free?

MassZymes is vegan and cruelty-free.

For the ingredient list used in this and other products, please refer to each specific product page for more details.

Can children take MassZymes? If so, what is the recommended dosage?

Children can take enzymes to help support digestion and better absorb the nutrients of the food they consume. A by-product is often noted as better mood and temper in children.

The recommended dosage is 1 capsule every 44 lbs body weight.

Check with your doctor or pharmacist prior to starting a new supplement.

Can I empty the contents of MassZymes capsules in a beverage?

The contents of the capsules can be dissolved in your beverage of choice.

Doing so will not improve nor diminish absorption or the health benefits you will obtain.

Is it okay for pregnant or breastfeeding women to take MassZymes?

This product is not recommended for pregnant or breastfeeding women.

Check with your doctor or pharmacist prior to starting a new supplement.

What is the recommended dosage for MassZymes?

Take 3 capsules with each meal. You may take 1-3 capsules with each meal and 1-2 capsules in between meals.

Digestive enzyme's role is to break down food. If you take it on an empty stomach, it won’t have any food to perform its function.

Check with your doctor or pharmacist prior to starting a new supplement.

  • Made in USA
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.5 inches
  • Bottom diameter: 2 inches
  • Height: 4 inches
  • Weight: 3.5 ounces


Do not use if ulcer or gastritis are present.


MASSZYMES - 365-Day Money Back Guarantee

All BIOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BIOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we'll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

365 Money-Back Guarantee

Why BIOptimizers Is A Different Kind Of Company

  • "BEST IN CLASS" guarantee: Our mission is focused on customer obsession. If after trying our products you don't feel we are the BEST IN CLASS, we will refund your money.
  • We work with 5 world-class formulators to create the best in class formulas
  • Customers love us: 5000+ positive product reviews
  • 99.3% customer satisfaction
  • We have helped over 570,000 legendary customers optimize their health since 2004
  • The 365 Day “Best Product Ever Or Your Money Back” Guarantee
  • One of the fastest growing companies in the USA - 2 years in a row
  • Experienced customer service: our happy health concierges are happy to help via phone at (800) 719-2467 or email [email protected]

BIOptimizers Was Born From Pain And Passion

Wade’s passion and mission for helping others optimize their health started when he witnessed his 23-year-old sister pass away from cancer. It was a heart-breaking experience that shaped his destiny. That’s when he realized that health was the most precious asset we have in this life.

Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months. He watched his friend’s entire life transform as a result. He went from never having a girlfriend to being married in just a couple of years.

Wade Lightheart

Wade Lightheart


Matt Gallant

Matt Gallant

Chief Executive Officer

Wade and Matt were both trainers working with pro athletes and other high performers. They both spent a decade in the gym helping people transform their health. Wade and Matt met in the gym, struck a friendship, and then started a business partnership that has been going strong since 2004.

That’s right, we started selling fitness programs, digestive enzymes and organic plant-based protein in 2004. Our obsession to build the best-in-class formulas and solutions just gets stronger. Our policy is, “If we can’t build the best product in that category, forget about it.”

We’re willing to go ALL IN on the formulas. What does this mean? Our average cost per bottle is 200% to 400% higher than most of our competitors. We use the optimal, effective doses of the most researched ingredients. We know that once you experience the results, you’ll be a fan of BIOptimizers for life.

Matt & Wade Matt & Wade
Matt & Wade Matt & Wade

Thank YOU for helping us become one of the fastest-growing companies in America - 2 Years in a row.

Thank you for trusting us with your health.


CEO/Co-founder of BIOptimizers


Scientific Studies
  1. Sinclair RD, Ryan TJ. Proteolytic enzymes in wound healing: the role of enzymatic debridement. Australas J Dermatol.1994;35(1):35-41. doi:10.1111/j.1440-0960.1994.tb01799.x
  2. Marzin T, Lorkowski G, Reule C, et al. Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ Open Sport Exerc Med.2017;2(1):e000191. Published 2017 Mar 12. doi:10.1136/bmjsem-2016-000191
  3. Mack DR, Flick JA, Durie PR, Rosenstein BJ, Ellis LE, Perman JA. Correlation of intestinal permeability with exocrine pancreatic dysfunction. J Pediatr. 1992;120(5):696-701. doi:10.1016/s0022-3476(05)80230-6
  4. André P, Laugerette F, Féart C. Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?. Nutrients. 2019;11(8):1887. Published 2019 Aug 13. doi:10.3390/nu11081887
  5. Blair MJ, Jones JD, Woessner AE, Quinn KP. Skin Structure-Function Relationships and the Wound Healing Response to Intrinsic Aging. Adv Wound Care (New Rochelle). 2020;9(3):127-143. doi:10.1089/wound.2019.1021
  6. Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. doi:10.1155/2012/976203
  7. Beck TW, Housh TJ, Johnson GO, et al. Effects of a protease supplement on eccentric exercise-induced markers of delayed-onset muscle soreness and muscle damage. J Strength Cond Res. 2007;21(3):661-667. doi:10.1519/R-21016.1
  8. S Vallabha V, Indira TN, Jyothi Lakshmi A, Radha C, Tiku PK. Enzymatic process of rice bran: a stabilized functional food with nutraceuticals and nutrients. J Food Sci Technol. 2015;52(12):8252-8259. doi:10.1007/s13197-015-1926-9

*These statements have not been evaluated by the Food and Drug Administration. Probiotic supplements are not drugs and therefore are not intended to diagnose, treat, cure, or prevent any disease or health condition.