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  • A nootropic blend that improves brain health, mental clarity, learning, memory, and focus by improving the gut bacteria
  • Helps with brain fog and procrastination
  • Promotes relaxation and balanced stress responses
  • Contains 17 nootropic and adaptogenic herbs that boost cognitive function, mood, and stress resilience by improving your gut flora
  • A powerful synergy of 10 brain-friendly probiotic bacteria strains, which have been shown to boost mood and cognitive function
  • Improves the balance of neurotransmitters, including acetylcholine, serotonin, GABA, and dopamine in the brain
  • Improves neuroregeneration and neuroplasticity by improving BDNF and NGF, which boost learning capacity and mood
  • Protects the brain against oxidative stress
  • Improves blood flow to the brain
  • Supports digestive health and regularity


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  • A nootropic blend that improves brain health, mental clarity, learning, memory, and focus by improving the gut bacteria
  • Helps with brain fog and procrastination
  • Promotes relaxation and balanced stress responses
  • Contains 17 nootropic and adaptogenic herbs that boost cognitive function, mood, and stress resilience by improving your gut flora
  • A powerful synergy of 10 brain-friendly probiotic bacteria strains, which have been shown to boost mood and cognitive function
  • Improves the balance of neurotransmitters, including acetylcholine, serotonin, GABA, and dopamine in the brain
  • Improves neuroregeneration and neuroplasticity by improving BDNF and NGF, which boost learning capacity and mood
  • Protects the brain against oxidative stress
  • Improves blood flow to the brain
  • Supports digestive health and regularity
Frequently Bought Together

Most nootropics and adaptogens only target the brain, which leaves out the key pieces of your cognitive function and mental health: your gut and the gut microbiome. CogniBiotics is the only probiotic-nootropic blend on the market that improves the entire gut-brain-microbiota axis.

The formula contains a powerful combination of 17 herbs known to provide mood support and enhance cognitive function by improving the gut microbiome. In addition, the 10 bacteria strains in CogniBiotics work synergistically to boost brain health and promote a balanced stress response.

  • Formulated by expert Chinese Herbal Scientists
  • The 2,200-year-old Chaihu-Shugan-San herb blend improves mood, brain health, and happiness through the gut microbiome
  • 10 research-based bacteria strains that synergize to improve mood and cognitive function
  • Prebiotic complex boosts probiotic survival and effectiveness
  • Adaptogenic: calming, promotes a balanced-stress response from the nervous system and mitigates negative health effects of stress
  • Nootropic: boost memory and learning, and maintain healthy brain function amidst stress
  • Improves mood and happiness
  • Protects the brain with antioxidants that can enter the brain
  • Supports neuroplasticity, which improves brain adaptation and healing
  • Can be taken on an empty stomach or with meals
  • 100% satisfaction guarantee with respect to quality, purity, potency, and effectiveness
  • Produced in small batches with medical-grade ingredients.


Proprietary Probiotic Blend (L. casei, L. rhamnosus, B. animalis, B. breve, B. longum, L. reuteri, L. helveticus, L. plantarum, B. infantis, L. fermentum), Prebiotic Complex (Organic Inulin, Xylooligosaccharides), Chinese Herbal Blend (Cristaria plicata, Reynoutria multiflora, Ligustrum lucidum, Salvia miltiorrhiza, Eclipta protrata, Cuscuta chinensis, Albizia julibrissin, Rehmannia glutinosa, Schisandra chinensis, Acorus tatarinowii, Bupleurum chinense, Paeonia lactiflora, Cyperus rotundus, Citrus aurantium, Ligusticum chuanxiong, Glycyrrhiza uralensis, Citrus reticulata

Other Ingredients: L-Leucine, silica, hypromellose (capsule).

Benefits of Taking CogniBiotics

  1. Improves Brain Health Through the Gut-Brain-Microbiome Axis

    Your gut feeling is an example of how your gut works with your brain. Recent research shows that gut health and the gut microbiome strongly influence brain health. Your gut bacteria can control your thoughts, emotions, and stress resilience. Also, many people with mental health and neurological disorders have dysbiosis and digestive issues. Often, an improvement in gut bacteria composition in these people improves their mood and brain function.

    CogniBiotics contain bacteria strains that are known as mood enhancers for their potential to improve cognitive function. In addition, the Chaihu-Shugan-San herb formula in CogniBiotics works by improving the dysbiosis and digestive issues. However, CogniBiotics is only meant for general brain health and not approved to treat any disease.

    • Boost BDNF (Brain-Derived Neurotrophic Factor)
    • Boost low mood
    • Reduce stress
    • Produce mood-boosting vitamins (e.g. K and B-12)
    • Rejuvenate your brain and improve brain-gut connection
    • Generate serotonin and happiness chemicals
    • Enhance cognitive performance
  2. Promotes a Balanced Stress Response and Stress Resilience

    Stress can cause poor sleep, abnormal appetite, reduced performance, and many other negative health effects. Adaptogens are herbs or substances that help support the nervous system to reduce the stress response, promote calmness, or improve your ability to deal with the stress. CogniBiotics contain several adaptogenic herbs such as Schisandra and Chinese licorice.

  3. Promotes Healthy Acetylcholine Levels

    Acetylcholine is an important neurotransmitter for learning and memory. P. multiflorum, S. miltiorrhiza, and R. glutinosa in CogniBiotics are cholinergic herbs that increase acetylcholine levels.

  4. Improves Neurotransmitter Balance

    In animal studies the probiotics L. plantarum, L. helveticus, L. fermentum, L. rhamnosus, and B. infantis promote the balance of serotonin, dopamine, and GABA in the brain. The good bacteria also help ensure that the used neurotransmitters are not converted into metabolites that may cause anxiety, brain fog, and neurologic disorders.

  5. Improves Brain-Derived Neurotrophic Factor

    The good bacteria and herbs in CogniBiotics work together to stimulate the production of proteins that help the brain grow, reorganize, and adapt. These proteins include brain-derived neurotrophic factor (BDNF) and neural growth factor (NGF). Increasing these proteins help with learning, memory, and mood.

  6. Protecting Neurons Against Oxidative Stress

    Oxidative stress comes from mental-emotional stress, toxic exposure, inflammation, poor diet, unhealthy lifestyle, and more. Nowadays, most people don’t consume enough antioxidants in their diets. When oxidative stress exceeds your body’s antioxidant capacity, it can damage cells. Oxidative stress can contribute to brain fog, fatigue, and neurologic disorders.

    Herbs in CogniBiotics contain antioxidants that can cross the blood-brain barrier and protect your brain from day-to-day oxidative stress.

  7. Increases Blood Flow to the Brain

    Your brain needs oxygen and vital nutrients to work well, but it’s also the organ that’s hardest to deliver blood to. It’s located at the highest point in the body and has many tiny blood vessels. Stress, poor blood vessel health, oxidative stress, and low blood pressure can reduce blood flow to the brain. When the brain gets reduced blood flow, it doesn’t get healthy levels of oxygen and nutrients. The deprivation can cause fatigue, brain fog, poor cognitive function, and low mood.

    The Chaihu-Shugan-San herb formula normalizes brain blood flow in patients with low mood.

  8. Producing Beneficial Postbiotics, Such as Butyrate

    Postbiotics are produced when your probiotic bacteria ferment the prebiotic fibers, such as the small fatty acids propionate and butyrate.

    Low mood, brain fog, and fatigue are caused by sluggish neurons that can’t produce enough energy (ATP). The small fatty acids can enter the brain, energize the sluggish neurons, and lower oxidative stress. Your neurons can also burn the fatty acids for energy. Butyrate also boosts BDNF levels.

    The small fatty acids also counteract chronic inflammation and strengthen the gut and blood-brain barriers. They also promote a healthy metabolism and blood sugar levels, which are important for brain health.

How CogniBiotics Works?

CogniBiotics combine the power of Chinese medicine with synergistic brain-boosting probiotics.

CogniBiotics contains two Traditional Chinese Medicine formulas traditionally used for both mental health and digestive issues by promoting harmony between the brain and the gut

  • The Chaihu-Shugan-San formula, which improves stress resilience, mood, and cognitive function by improving the gut flora
  • The An Shen Bu Xin San formula, traditionally used to calm the spirit, contains several cognitive performance-enhancing herbs

These herb formulas were invented 2,200 years ago, but modern-day research has shown that they boost neurotransmitter levels, improve the gut microbiome, and combat oxidative stress. They are also adaptogenic herbs that promote a balanced stress response.

The beneficial bacteria boost mood, wellbeing, and memory while promoting a balanced stress response by:

  • Directly speaking to your brain via the vagus nerve that links between the gut and the brain
  • Controlling your neurotransmitters, such as the happy neurotransmitter serotonin, rewarding neurotransmitter dopamine, and relaxing neurotransmitter GABA
  • Producing beneficial nutrients that can jump-start sluggish neurons and combating oxidative stress
  • Boosting neuronal growth and branching, by increasing a protein called BDNF, which improves happiness and memory
  • Promoting a healthy and balanced stress response
  • Promoting a balanced inflammatory response, since excess inflammation can contribute to mental health and cognitive problems

When To Take CogniBiotics?

The goal is to deliver the probiotics to your large intestine relatively intact and maximize absorption of the herbs, so you want to minimize their exposure to your stomach acid and digestive enzymes. Your gut secretes digestive enzymes and stomach acid when you have food in your stomach. Therefore, you should take your CogniBiotics on an empty stomach. However, if you get stomach upset from taking it without food or cannot take it without food for any other reasons, it is still beneficial when taken with meals.

Take CogniBiotics first thing in the morning on an empty stomach. Some people also find significant cognitive and mood boosts when they take CogniBiotics before or with lunch and dinner.

Because CogniBiotics contain probiotics, be sure to take it at least an hour away from antibiotics or dietary supplements that have antibacterial properties.

CogniBiotics and Depression

The latest research shows that, aside from life events, the following factors contribute to depression, cognitive dysfunction, and other mental health problems:

  • Imbalanced gut microbiome
  • Sluggish neurons in the brain due to mitochondria dysfunction
  • Overactivated stress response
  • Increased inflammation
  • Intestinal permeability
  • Abnormal circadian rhythm or sleep patterns
  • A leaky blood-brain barrier
  • Unstable or poor blood sugar control
  • Nutrient deficiencies, such as omega-3, B vitamins, minerals, and amino acids

CogniBiotics promotes good mood, mental health, cognitive function, and stress resilience by:

  • Improving the gut microbiome
  • Energizing the neurons
  • Promoting a balanced immune response
  • Supporting the gut and brain barriers
  • Promoting digestive health
  • Supporting blood sugar control (Blood Sugar Breakthrough)

Ultimate Biological Optimization Program

CogniBiotics Questions:

What is the recommended dosage for CogniBiotics?

The recommended dose for CogniBiotics can be found on the label - 2 capsules a day on an empty stomach upon waking.

However, in clinical experience, we have found the effective dose for most people is 2 capsules in the morning, 2 capsules with breakfast, and 2 capsules in the evening.

If you want to start slow, take 2 capsules with breakfast and 2 capsules with dinner.

Can children take CogniBiotics? If so, what is the recommended dosage?

CogniBiotics is safe for children. The recommended dose is 1 capsule for every 40 lbs.

Consult your medical practitioner prior to starting any new supplement.

Can you empty the contents of the capsule in your beverage?

The contents of the capsules can be dissolved in your beverage of choice. Doing so will not improve nor diminish absorption or the health benefits you obtain.

Will CogniBiotics, since it is a probiotic, replace P3-OM?

No, because they contain different bacteria strains that serve different purposes. With a synergistic blend of synbiotics (pre+probiotics) and Chinese herbs, Cognibiotics is engineered to improve mood and brain function through boosting the gut bacteria. Whereas P3-OM contains the best researched strain of probiotic to boost your digestion and assimilation of proteins, along with your immune function.

What are the benefits of taking CogniBiotics?
  • Boosts brain health and the health of the gut-brain axis
  • Promotes a balanced stress response and stress resilience
  • Promotes the balance of serotonin, dopamine, and GABA, which is important for happy and calm mood
  • Increases acetylcholine, which is important for memory
  • Reduces toxic neurotransmitter metabolites, which may cause brain fog or anxiety
  • Increasing brain-derived neurotrophic factor and nerve growth factor, which are important for learning, memory, and good mood
  • Protecting neurons against oxidative stress
  • Increasing blood flow to the brain
  • Stimulating the vagus nerve, which promotes relaxation and may reduce inflammation
How many capsules in a CogniBiotics bottle?

The CogniBiotics bottle contains 60 capsules.

What is the shelf life of CogniBiotics?

The shelf life for CogniBiotics is 2 years from the manufactured date, which can be found on the bottle.

Is it okay for pregnant or breastfeeding mothers to take CogniBiotics?

Pregnant or breastfeeding mothers should consult a medical practitioner prior to starting any new supplement, diet, or training program.

Can you multiply cultures with CogniBiotics?

The probiotic in CogniBiotics cannot be cultured at home because it contains other ingredients such as herbs and prebiotics.

If you’re looking to culture probiotics, we suggest using P3-OM.

How should CogniBiotics be stored?

Store CogniBiotics in a cool and dry place.

  • Made in USA
  • GMP Certified
  • Manufacturing COA

Product Information

Product Dimensions:

  • Cap diameter: 1.58 inches
  • Bottom diameter: 1.95 inches
  • Height: 3.78 inches
  • Weight: 1.98 ounces


Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you’re undergoing treatment of a medical condition.


COGNIBIOTICS - 365-Day Money Back Guarantee

All BIOptimizers products come with a 365-Day Money Back Guarantee. If you are not completely satisfied with your BIOptimizers product for any reason between today and 365 days from now, just send back your remaining unopened bottles of the product and we'll give you a full refund (minus the cost of shipping and handling). If you open a second bottle, you no longer qualify for any guarantee. Reach out to our customer happiness team and they will take complete care of it.

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Why BIOptimizers Is A Different Kind Of Company

  • "BEST IN CLASS" guarantee: Our mission is focused on customer obsession. If after trying our products you don't feel we are the BEST IN CLASS, we will refund your money.
  • We work with 5 world-class formulators to create the best in class formulas
  • Customers love us: 5000+ positive product reviews
  • 99.3% customer satisfaction
  • We have helped over 570,000 legendary customers optimize their health since 2004
  • The 365 Day “Best Product Ever Or Your Money Back” Guarantee
  • One of the fastest growing companies in the USA - 2 years in a row
  • Experienced customer service: our happy health concierges are happy to help via phone at (800) 719-2467 or email [email protected]

BIOptimizers Was Born From Pain And Passion

Wade’s passion and mission for helping others optimize their health started when he witnessed his 23-year-old sister pass away from cancer. It was a heart-breaking experience that shaped his destiny. That’s when he realized that health was the most precious asset we have in this life.

Matt’s passion and purpose for helping others started when he helped his best friend lose 191 lbs in 18 months. He watched his friend’s entire life transform as a result. He went from never having a girlfriend to being married in just a couple of years.

Wade Lightheart

Wade Lightheart


Matt Gallant

Matt Gallant

Chief Executive Officer

Wade and Matt were both trainers working with pro athletes and other high performers. They both spent a decade in the gym helping people transform their health. Wade and Matt met in the gym, struck a friendship, and then started a business partnership that has been going strong since 2004.

That’s right, we started selling fitness programs, digestive enzymes and organic plant-based protein in 2004. Our obsession to build the best-in-class formulas and solutions just gets stronger. Our policy is, “If we can’t build the best product in that category, forget about it.”

We’re willing to go ALL IN on the formulas. What does this mean? Our average cost per bottle is 200% to 400% higher than most of our competitors. We use the optimal, effective doses of the most researched ingredients. We know that once you experience the results, you’ll be a fan of BIOptimizers for life.

Matt & Wade Matt & Wade
Matt & Wade Matt & Wade

Thank YOU for helping us become one of the fastest-growing companies in America - 2 Years in a row.

Thank you for trusting us with your health.


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Scientific Studies
  1. Yu M, Jia HM, Zhang T, et al. Gut Microbiota is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San. Metabolites. 2020;10(2):63. Published 2020 Feb 10. doi:10.3390/metabo10020063
  2. Morais, L. H., Schreiber, H. L., 4th, & Mazmanian, S. K. (2020). The gut microbiota-brain axis in behaviour and brain disorders. Nature reviews. Microbiology, 10.1038/s41579-020-00460-0. Advance online publication.
  3. Cryan JF, O'Riordan KJ, Cowan CSM, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877-2013. doi:10.1152/physrev.00018.2018
  4. Yu M, Jia HM, Zhang T, et al. Gut Microbiota is the Key to the Antidepressant Effect of Chaihu-Shu-Gan-San. Metabolites. 2020;10(2):63. Published 2020 Feb 10. doi:10.3390/metabo10020063
  5. Howes MR, Fang R, Houghton PJ. Effect of Chinese Herbal Medicine on Alzheimer's Disease. Int Rev Neurobiol. 2017;135:29-56. doi:10.1016/bs.irn.2017.02.003
  6. Wang H, Lee IS, Braun C, Enck P. Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review. Neurogastroenterol Motil. 2016;22(4):589-605. doi:10.5056/jnm16018
  7. Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ. Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status. Int J Tryptophan Res. 2019;12:1178646919852996. Published 2019 Jun 19. doi:10.1177/1178646919852996
  8. Ohland CL, Kish L, Bell H, et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. sychoneuroendocrinology. 2013;38(9):1738-1747. doi:10.1016/j.psyneuen.2013.02.008
  9. Feng DD, Tang T, Lin XP, et al. Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review. Neuropsychiatr Dis Treat. 2016;12:2387-2402. Published 2016 Sep 20. doi:10.2147/NDT.S114560
  10. Qiu J, Hu SY, Shi GQ, Wang SE. Changes in regional cerebral blood flow with Chaihu-Shugan-San in the treatment of major depression. Pharmacogn Mag. 2014;10(40):503-508. doi:10.4103/0973-1296.141775
  11. Fukuda S, Nojima J, Motoki Y, et al. A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity. Biol Psychol. 2016;118:88-93. doi:10.1016/j.biopsycho.2016.05.005
  12. Schönfeld P, Wojtczak L. Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res. 2016;57(6):943-954. doi:10.1194/jlr.R067629
  13. Chambers ES, Preston T, Frost G, Morrison DJ. Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep. 2018;7(4):198-206. doi:10.1007/s13668-018-0248-8
  14. Braniste V, Al-Asmakh M, Kowal C, et al. The gut microbiota influences blood-brain barrier permeability in mice [published correction appears in Sci Transl Med. 2014 Dec 10;6(266):266er7. Guan, Ng Lai [corrected to Ng, Lai Guan]]. Sci Transl Med. 2014;6(263):263ra158. doi:10.1126/scitranslmed.3009759
  15. Puddu A, Sanguineti R, Montecucco F, Viviani GL. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm. 2014;2014:162021. doi:10.1155/2014/162021
  16. Limbana T, Khan F, Eskander N. Gut Microbiome and Depression: How Microbes Affect the Way We Think. Cureus. 2020;12(8):e9966. Published 2020 Aug 23. doi:10.7759/cureus.9966
  17. Allen J, Romay-Tallon R, Brymer KJ, Caruncho HJ, Kalynchuk LE. Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression. Front Neurosci. 2018;12:386. Published 2018 Jun 6. doi:10.3389/fnins.2018.00386
  18. Keller J, Gomez R, Williams G, et al. HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition. Mol Psychiatry. 2017;22(4):527-536. doi:10.1038/mp.2016.120
  19. Raison CL, Miller AH. Is depression an inflammatory disorder? Curr Psychiatry Rep. 2011;13(6):467-475. doi:10.1007/s11920-011-0232-0
  20. Calarge CA, Devaraj S, Shulman RJ. Gut permeability and depressive symptom severity in unmedicated adolescents. J Affect Disord. 2019;246:586-594. doi:10.1016/j.jad.2018.12.077
  21. Walker WH 2nd, Walton JC, DeVries AC, Nelson RJ. Circadian rhythm disruption and mental health. Transl Psychiatry. 2020;10(1):28. Published 2020 Jan 23. doi:10.1038/s41398-020-0694-0
  22. Shalev H, Serlin Y, Friedman A. Breaching the blood-brain barrier as a gate to psychiatric disorder. Cardiovasc Psychiatry Neurol. 2009;2009:278531. doi:10.1155/2009/278531
  23. 1. Kay, MPH, RDN I. Is Your Mood Disorder a Symptom of Unstable Blood Sugar? School of Public Health, University of Michigan Published 2019. Accessed January 26, 2021
  24. Rao TS, Asha MR, Ramesh BN, Rao KS. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008;50(2):77-82. doi:10.4103/0019-5545.42391

*These statements have not been evaluated by the Food and Drug Administration. Probiotic supplements are not drugs and therefore are not intended to diagnose, treat, cure, or prevent any disease or health condition.