This episode’s guest loves to teach.
Being an assistant professor or adjunct professor is one of Don Moxley’s favorite parts of his resume. He’s a scientist at heart who navigates his academic career by staying on the fringes of the university where he teaches – keeping his hands free from the handcuffs of whatever dogma the institution professes. Don loves to teach. However, he is not interested in getting comfortable in a college ivory tower.
This is why Don stays nimble in his health and wellness work by working directly with innovative health brands.
Trained as an exercise physiologist, Don likes to keep a foot in the wearable technology industry. He has also worked for years in the high-performance athletics field – primarily collegiate wrestling. Don was a good wrestler himself back in college and has spent much of his career working with college wrestling programs, helping athletes reach their full potential.
At the beginning of 2017, Don made a significant shift in his mindset by changing how he approached life by operating through his mission statement instead of operating life through definition. His mission is “understanding and directing individual changes that alleviate suffering and contribute to the betterment of well people.”
This new approach to his career and life opened up tremendous opportunities to grow and impact his community.
Currently, Don works with Longevity Labs, an Austrian company, and is helping launch their flagship product, spermidineLIFE.
This molecule with the funny name provides serious help to our cells, impacting human longevity, how you feel in the present, and your ability to live a quality life as you age.
Tune in as Wade and Don discuss this little-known health agent that biohackers are getting excited about.
In this podcast, we cover:
- Don’s career journey in athletics, academia, and cannabis
- What is “heart rate variability,” and how it provides insights into an athlete’s potential success
- What “spermidine” is and how it can contribute to longevity
- The benefits to fasting and intermittent fasting
- How spermidine is measured in the body
- The physical benefits people experience after supplementing with spermidine
- The one type of food you want to consume when you take spermidine
High-Performance Athletics and Cannabis
At one point, Don speaks about his experiences working in the cannabis industry, where he did a deep dive into understanding the human endocannabinoid system, a portion of his career Don calls “an incredible opportunity.”
Here is a snippet of what he said on this episode: “I think if you’re trying to do high-performance athletics, and you’re not at least trying to understand cannabinoids and terpenes, you’re kidding yourself.”
“I think when you measure HRV, you measure endocannabinoid system status, and you can modify it. While I was doing that, I get a call from a buddy in Austria. He asks, “What are you doing?” He tells me about this company that’s focused on autophagy.”
“I had not done a deep dive into it yet. He then says, ‘have you ever heard of a molecule called spermidine?’ I had not. He says, ‘I want you to do the same thing for us that you did in Florida for the cannabis brand.’
“Today, I’m their director of applied science and brand development. So, my job is to help this company build a brand that’s based on science. And that’s what we do.”
“So now I’ve gone down the rabbit hole of autophagy and polyamines.”
You need THIS for a long, healthy life…
The one thing you must be doing for a long, healthy life, according to Don, is autophagy, which is, in layman’s terms, your body’s natural process of recycling cells.
Don tells Wade, “There is no doubt in my mind that to live healthy, to get the most out of your healthspan and lifespan, you have to have good autophagy. Intermittent fasting or fasting is the shortest pathway to that. And spermidine helps. No doubt about it – you increase spermidine, then your autophagy increases as well.”
“You also need to eliminate sugars. It’s one of our biggest challenges as a society. I call it caloric toxic. We have so much access to sugary drinks.”
“On the other end of the spectrum, you move from caloric restriction and autophagy and then into intermittent fasting and longer fasting, ceremonial fasting. There’s a reason why it’s included in every major religion in the world. Health benefits come from it.”
“What’s old is new, and old is leading the way,” replied Wade.
Tune in to find out what spermidine can do for your health, energy, and quality of life. Don Moxley is a science-based researcher with a diversity of subject matter areas. He is good at connecting the dots, revealing connections between spermidine, autophagy, fasting, strength training, our endocannabinoid system, cannabis, and our ability to live a longer, higher quality life through diet, exercise, and supplementation.
Check out this episode – spermidine could revolutionize your health!
AHP Listeners get 15% off with code: Wade15 on spermidineLIFE
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Read The Episode Transcript:
Wade Lightheart: Good morning. Good afternoon. And good evening. It's Wade T Lightheart from BiOptimizers with another edition of the Awesome Health Podcast. And I'm delighted to share with you our guests from longevity labs. Our guest is Don Moxley, who is a trained exercise physiologist and has spent 25 of the last 35 years as an assistant, an adjunct professor while teaching Donnie has kept a foot in wearable technology industry and high performance athletics beginning in 2017, Don made a major change. His life began operating via personal mission rather than definition. Hmm, that's a good one to talk about his mission understanding and directing individual changes that alleviate, suffering and contribute to the betterment of well. People has led to some amazing opportunities to learn and impact the community around him. And he currently works with longevity labs, an Austrian company, and is launching their flagship product called Spermidinelife. We're going to talk about that in a little bit, and it's basically, it's an amazing molecule has a direct impact on longevity and healthy aging. Don, welcome to the show. Don Moxley: I'm excited to be here. Wait, I've been looking forward to this one. Since we met, we Wade Lightheart: Just met recently at the wake up orange county events. And for those who don't know that we are big supporter of the bio logical optimization, biohacking longevity, health optimization technology that wake ups are becoming famous for. And now that we have meetups in the real world, it's really nice to connect with other like-minded people. And of course we had a booth rate literally beside each other at the most recent event. And you were telling me about some unique research on longevity and this summertime product, but maybe before we get into that, we might want to share with our listeners kind of how you got to where you are today, your background and all that sort of stuff. Don Moxley: Well much like your story. What I heard you tell is I grew up on a farm in Eastern Ohio. We raised at one time we had up to 2000 head of beef cattle. And I finished up high school there with every intention of going to Ohio state and studying agriculture and going home and feeding beef cattle. Now I was a decent high school wrestler. Won a lot of matches, did pretty good. So I decided to walk on the wrestling team at Ohio state now that was a bit of a challenge. I, I, the first year I practiced about 15 days injured in knee, had surgery on, it was basically done. I used to cut a lot of weight. You know, I currently walk around at about 275 pounds. And I'm the smallest brother. I have two brothers and I'm the smallest of the three. Don Moxley: I have a younger brother that's six, nine, and a, probably a biscuit over three 50. And and so, but I used to cut from about two 30 to 1 77. Didn't pay off came back sophomore year. We had a returning All-American at 1 77. So I moved up to one 90 did twice as well. That year practice, 30 days hurt the other knee, had surgery on it and had to start asking, you know, what does it take to be successful in wrestling? And now I had, I had this intersection that was just an amazing state, was an amazing place to be back then that our strength coach and the athletic department had come from the university of Nebraska and one of his graduate assistants, a guy by the name of Ted Lambert, Lamborghinis, Ted is famous in the strength and conditioning circuit. I had one of my college roommates teammates had a roommate by the name of Kevin Akins. And at the time Kevin Akins had the third longest shot in the world. And he said, if you want to get strong, I'll take you where you get strong. And he walks me into Louie Simmons's garage. Wade Lightheart: I was going to say the west side barbell Calum must've been connected there. So before Don Moxley: West, and this was before west side was really west side, right? This was early Louis had, he had moved out of his basement up into his garage. And there was just this amazing group of mutants working their way through this facility. I'm like, okay, this is interesting. And then I had a professor at Ohio state. His name was Robert Bartells Dr. Robert Bartells. He was a protege to the American researcher that actually described energy systems. So when you take a look at how we generate energy ATP, PC glycolytic and an oxidate of well ed Fox was, was Bob Bartell's mentor. And so I've got this great intersection of just three excellent mentors. I started to get strong and I started to get a lot better. I finished up at Ohio state in 85 won a big 10 title captain the team. I still have a couple of records that still stand for fall. So, you know, for a kid from Barnesville, I wound up making pretty good. And, but fell in love with exercise physiology finished up my graduate work, finished up my undergraduate finished up grad school in three quarters there and have been in exercise science ever since. Wade Lightheart: That's beautiful. I always love those background stories. And so what is you, you talked about a mission shift a few years ago. There was a, there was a shift and this oftentimes happens, you know, people kind of go down a career or there seems to be a series of doesn't look like connections, but all of a sudden there's like, there's like a watershed moment. And then like all kind of jealous together. Was there something like that that happened in your life that kind of put you where you are today? Don Moxley: Well, I was, I was forced to do this, that, as you said earlier, you know, I've been in in front of a classroom almost ever since I got out of grad school. I love teaching it's one of my favorite things to do in the world. But I am, you know, when you start teaching at a collegiate level, if you're not tenure track, if you're not working on that PhD, you know, you're kind of an odd oddity. I don't, I, I, I never had a desire to, to finish the PhD and go down that road. But I love to study. I love to learn and I'd finished up teaching at a small college in Western Ohio. And actually the wrestling coach at Ohio state came to me and said he needed some help with his team and stepped in and assisted with one of his wrestlers. Don Moxley: And we figured some things out, looking at training, recovery, understanding heart rate variability, and how to apply training loads and so forth. And I wound up working as a sports scientist at Ohio state from 2015 through 18 that 17, 18 season. We measured three and a half million data points on a wrestling team. We were working, we were working with the air force research lab out of Wright Patterson air force base. So our data was being incorporated with Naval special operators and, and Delta force and all the special operations groups. So it was, it was an amazing experience. But what I learned is as Ohio state didn't particularly want me there. I was an outlier again, I was not part of the traditional college athletic department, strength and conditioning dogma. I was a scientist that was looking at, listen, these things that you're saying may not be true, let's figure out what's true first before we start to convert them to, to, to, to, you know, to religious doctrine. Don Moxley: So and I was, I was basically forced to leave. I couldn't afford to stay there. And, and about the same time I got an invitation to go work in the cannabis industry down in Florida. And I Ronica early while I was working in the sports science. I had another one of these inter interactions of, of multiple vectors that at some of my friends, from the wearable industry reach out to me cause they knew I did heart rate variability. They knew it was important to me. And they said, what do you know about cannabis in HRV? And I said, well, I said, my athletes are all NCAA athletes. So we, it, cannabis is not part of the program, but I started to do some research and I said, whoa, there's something here that we need to understand. And and I was made just a wonderful offer. It was like, you know, it was the universe saying, you know, you can stay here and struggle at Ohio state or you can, you, you can change your life right now. And so how do you go from college professor athletic department, sports scientist to selling weed in Florida? Wade Lightheart: There's a, there's an interesting I want to unpack that a little bit because recently we entered into a starting a couple of years ago and we've solidified that with our company with a research university in Croatia. And so we have now a corporate and institutional relationship where they have what I would say, the intellectual horsepower that we need to kind of have breakthroughs. We have the financial means to get them the testing equipment that allows them to get data points. I want to tie this in, because I think this is pertinent because I'm a big fan of listening to Bret Weinstein, the evolutionary biologists. And, you know, he's got a podcast called dark horse and he talked about specifically him and his brother, Eric, Eric has, Eric's a little bit harder to relate to. He's like a super G they're both extraordinary intellectuals, but they were talking about this institutional rot that is happening where just within their sphere of influence, there is mega breakthroughs in a variety of areas, which is essentially going unreported and undistributed to the world. And now many of these, you know, intellectuals and people who are on the bleeding edge are in this kind of, well, they're in this no man's land as if they stay with the institution, which, you know, has tenure, or has the sort of a place where you can, you know, Don Moxley: Get in, you're handcuffed in, you're handcuffed Wade Lightheart: In, but you're, you're what your breakthroughs are. What you're trying to betterment society are going to get buried inside of the institutional gobbledygook. And yet many of them are having reservations of moving into the commercial practice because of, you know, some of the unsavory aspects of certain corporations. But then again, also recognize that that is the best place where you can distribute ideas to the world. How, what would you say you, and this is for all our intellectuals who might be facing this dilemma, what, how did you walk yourself through that decision to say, Hey, you know what, I've gone as far as I can go here. I, and I, and I I'm instill in pursuit of the truth and now I need to get a, kind of a a corporate partnership that allows me to do what I do. What was that like for you? Don Moxley: And I, I have to tell you what's come out of this for me, is that while I consider myself an absolute scientist, there's no two ways about it that while I, while I absolutely live and breathe the science, I think you make decisions based on evidence. I am not bound by peer reviewed double-blind evidence. Is that what we need? No. Is that you can have evidence, you have clinical evidence ahead of the studies, and this is what this is what creates opportunities. And if you're going to be in high-performance human high human performance, you can't wait for things to come out in medicine, science, sports, and exercise, or, or, or certified strength and conditioning. You have to be functioning at a different level. Now, with that said, there's a lot of people operating in these systems that frankly are operating, using the next thing to religious dogma. Don Moxley: And the fact that if this is my program, this is how we do it. This is our setting. I'm Westside, I'm hit I'm this I'm that, here's what we learned from our data, with the wrestling team. I had, we, we qualified the entire starting lineup for nationals. My last year there, 10 guys school, first time in school history. Now I had two different strength coaches. I was working with fair on the team, and we actually had four. So individual guys had people they like to work with. We had the university string coach. We had a string coach for our art teacher. I see. And so let's say three. And the question is, who do you follow? Because they each had their own dogma. And I sat back and I said, listen, there's no evidence that any of your programs is better than any of the others. Don Moxley: So I'm going to let the athletes make the choice. We are going to do strength work. We know strength is important. And we see that across from high performance to longevity. It's, it's, it's a key element, but what you do has has yet to be determined. So we send 10 guys to nationals. Three of them are, oh, from one program, three from the other and four from the third. So it's as close to an even break as you can get. We had eight all Americans to three and three. Okay. Again, close to an even break. So what I learned from, and that is, and again, they're three completely different programs. One was a very high I would say low volume, high intensity. One was a kind of a bodybuilder program and the other ones are traditional college. [inaudible] You know what, what I know now, and, and as a, as a professional number one, I don't, I don't care what you do. Don Moxley: Weight room. There are some basic, there's some basic things, things you need to do. Don't get me wrong. I do care. There's some basic things, but I'm not going to get hung up in programs. I'm not I'm, you know, when I was teaching this little school I was teaching at, in Western Ohio, one of my, one of my students kept saying, man, I'm a west side guy. I'm a west side guy. And I'm like, listen, you know, I've known Louis Simmons for, for almost 35 years. I love what he teaches. I love it's a great program. I said, but understand whether it's west side or hit or Nebraska or volume, listen, this is the difference between Baptist and Catholics and Methodists and Episcopalians. We all study from the same book. Okay. The rules changed, but it's all from the same book. And this is an important part of what I learned that year and from a sports science standpoint, what we identified. Okay. So I'll ask you this question. We were, we were a wrestling team. Okay. When you think of a wrestling team, should the training be, and this will be two big categories should be aerobic or anaerobic. Wade Lightheart: That's a good question because you're in a, you're in a, you're in both essentially, because you need explosive power, but you, if you run out of endurance capabilities, you're going to be gassed out on the mark, on the mat. Don Moxley: And, and so what we did, so again, I measured again, we had three and a half million data points to work from, including heart rate, variability, recoverability, strength, cardio, all these things. So I took my team and we broke them into three groups. So I had a group of nine guys that were all Americans or better. So they're all Americans national champions, or I had two Olympians and two world champions in that group. I had a group of guys, I think the end on that was 12 or 15 that had, were able to wear the uniform for us and, and, and get into a point scoring situation with the team. But we're never able to make it to big tens to achieve All-American status. And then I had a group that never wore the uniform. Now these, the guys that never wore the uniform were you had two and three time state champs in that group. Don Moxley: There were some talented kids and these kids came in and rustled with my group one and two every day. Right? So they're not, they're not, these are good wrestlers. The number one factor for determining your ability to move from group three to group one, VO two, fascinating. So when you look at it, it's not necessarily like a marathon or [inaudible], but your ability to win a wrestling matches about your ability to recover your ability to go to the edge. You go out of bounds, you come back and this, and so this ability to recover and ultimately you're generating energy throughout the match, the athletes can generate the most energy has an advantage. Well, you build your cardiovascular system and that was the number one predictor strength. So we used it. So we did bench, press, squat, deadlift Wade holds pull ups. The, the only thing that determined your ability to move from group three to group two was your ability to deadlift two times your body weight. Don Moxley: If you couldn't deadlift two times your body weight, you probably get into group to group all a group. One could do that too. The thing that determined whether you could move from group two to group one, pull ups and waited and waited grip strength. So your ability to hold your body weight. So we put half their body weight in each hand and measure how long they could hold it, or we would do pull-ups. So muscular endurance determined your ability to move from group two to group one. Now that goes against all university based strength and conditioning, dogma bench press predicted nothing, right? Okay. Squats predicted nothing. And, and one of our challenges is that what is the culture that you establish in the room? And what is the culture you establish with your team? My coach would, I was in way too many meetings where they said, we need a bench press club. Don Moxley: And I said, there's no way you're doing a bench press club while I'm part of the staff. You can bench press. I didn't say don't bench, press just don't celebrate it. We squatted, we front squatted. We did trap bar dead lifts. We worked at posterior chain hard, but we didn't celebrate it. That was nothing on the wall. What you celebrate are the things that make a difference that you want people to, to engage in. And then finally that when, when, so that last year we sent 10 guys to nationals we had eight All-Americans they'll set a school record. I could have told you the two guys that would not make all American the first day of the tournament, based on heart rate variability, based on their, their ability to recover. And by that time, we've gotten to the point to where I could almost determine whether someone would win or lose a match that by measuring them that morning based on recovery. Wade Lightheart: Wow. So where that person's HRV was, would be a good indicator of what, like, basically, because at this point you're dealing with such of a low variance between the skill of the athletes. Like how ready are they on that particular day is going to oftentimes when the day is basically what you're saying exactly. Don Moxley: Well, and, and again, we're competing. So while we were there, we, we won a national title. We finished second or third, every other year, one big is three years, you know? And, and so we're winning big tens beating Penn state, but we lost to them twice. We finished second to them twice at national. So, you know, the, the top teams in the country at the time were, were Penn state, Ohio state, Iowa you know, Oklahoma, state's good, but, and we're, we all recruited the same kids. You know, every, every kid that we saw wrestle in someone else's Jersey we had had in, on a recruiting trip, but for some reason we lost them. Right. so, you know, we're putting race horses in the barn. We were training them hard. We had good skills. So literally the determining factor at that level was your ability to recover and get the three or four, three to five match wins that you need to make all American. Don Moxley: And when we see this at a lot of levels, so, you know, this was listen, it was a great experience. And so what I was saying is that, wait, I believe there's more to our existence than just what we see in front of us. I think your lead, I feel why I feel a very strong I'll use the term spiritual lead. I think the universe said, you're done here. You've done all you can. You've moved the needle all you can. It's time for you to go to a new place. Went down to Florida, worked in the cannabis industry, did a deep dive into understanding the endocannabinoid system cannabis, which was just an incredible opportunity. I don't think you can listen. I think if you're trying to do high performance athletics, and you're not at least trying to understand cannabinoids and terpenes, you're kidding yourself. Don Moxley: It's an absolute I think when you're measuring HRV, you're measuring endocannabinoid system status and you can modify it. And then while I was there, met a guy and I get a call one day and says, Hey, what are you doing? He said, I've got this buddy in Austria. They've got this company. I was passively I was passively recognized the term autophagy. I had not done a deep dive into it yet. He said, have you ever heard of a molecule called [inaudible]? And I had not. and he said, well, he says, I want you to do the same thing for us, that you did in Florida for that, for that brand. I'm the director of applied science and brand development. So, you know, our, our, my job is to help this company build a brand that's based on science. and so that's what we do. So now gone down the rabbit hole on the top of G and poly Amiens and things Wade Lightheart: That's really, really great. And so that kind of picks us up where we met. You were talking about the science and development around this particular molecule. Maybe you can share with us what sperma dine is, what was the etymology or the history of how it came in, then how you became a part of sharing this with, with people around the world, how it got Don Moxley: The freaking crazy name. So Spermidine is a molecule we've known about for hundreds of years. It was first described in the late 17 hundreds on Tom Von lo and hook who invented the microscope. He used, he was a field fabrics, textile salesperson, and they invented the microscope for counting fabric counts, thread counts and fabrics. And so literally the, the, you know, they call him the father of microbiology. He was really the father of figuring out how to count threads and out of it came this microscope. Well, he's enough of a freak that after he gets his microscope, somehow semen winds up on one of the slides. He winds up looking at that. So I don't know if he was trying to see if his swimmers had his look like him or not. I don't know. But they described a, they described a crystal Instructure in the semen, and that's the first time it was ever discussed. Don Moxley: It, got the name about 200 years later in the late 18 hundreds. But then as we move into the late 19 hundreds, you really start to see the emergence of the study of sperm benign as an active molecule. And what we know now, Wade is that it is a molecule that is in every cell of your body, men, women, plants, and animals. It's a very important molecule in a process that's called autophagy this, this cellular cleaning cellular renewal process. Now w we're pretty cutting edge here. You know, they just gave a Nobel prize in 2017 to a Japanese Reacher researcher for describing the, of G. So we've just really starting to understand that process. But what we know based on the research from one of the founders of our company, a guy by number of Dr. Frank [inaudible] Frank with his research saw that spermatids supplementation in human senescent cells caused them to be non senescent anymore. Don Moxley: They didn't go through a pop TOSAs. They didn't go through a self Def. So this is where they really started to look. And, and what we know now, Wade is that again, we all have, we all have spermicide in our bodies, but it starts to decline as we age. But people who age well into their nineties and hundreds have Spermidine levels similar to those in their thirties. Okay. so that, you know, we have that epidemiological data to support that we have some recent research that shows that consuming sperma nine orally raises sperma nine levels in yourselves. It also crosses the blood brain barrier. So we know it's impacting above the net. We, we have a lot of wonderful mental effects coming from spermicide supplementation, improve cognition, improved hippocampus thickness D thickness of the brain that's typically victimized by Alzheimer's disease. Don Moxley: So it has a positive relationship there. We know that populations that live in blue zones have high spermicide diets. And, and so when we start taking a look at, at sperma nine, it is a, it's one of those interesting molecules. We harvest ours from wheat germ. Again, we're an Austrian company. We get wheat germ from central Europe, you know, Southern Germany, Austria, Northern Italy, Switzerland. And, and we have a process of extracting and refining the wheat germ into a high and concentrate. And that's what we sell in our product called sperma nine life. Wade Lightheart: That's fascinating. You know, I, I remember Arnold Schwartzenegger back in the day thing, wheat germ, as part of his shake strategy back in the seventies. And of course he comes from Austria. So it's a metabolic theory about some learning that's, this is fascinating. And I think for our listeners, many who are engaged in intermittent fasting, or understand the principles between why caloric restriction, autophagy you know, can, can enhance what they feel is life expectancy and a variety of other conditions. But I think for some people that's a very difficult endeavor. And so what you're potentially suggesting is that through a supplementation, you can get the, w would that be, they say that you would get some of those [inaudible] benefits from not from maybe from the fasting side, but just from what is the mechanism like, what's, what's the piece that's kicking that up. Don Moxley: I think certainly from a marketing standpoint, yeah. You serve a nine as a product that gives you a, a G without fasting from a, from an exercise science or from a scientist standpoint. Wade, I believe listen that our nutrition, our understanding of nutrition comes from university studies for the most part. Right, right. And, and I've over the 25 years, I've probably taught nutrition a half a dozen times, and we teach it using a textbook. You know, the textbook is what we call Wardwell nutrition. And it's, it's, it's proteins, fibers, proteins, fats, carbohydrates, vitamins, minerals, water, you know, we teach the six nutrients and then we spend time talking about food labels and, and that's, that's what I call Wardwell nutrition. Personally, you know, I believe, I believe Tassa G will be included in textbooks a decade from now. Don Moxley: I think it'll take that long for it to clear the academic circles and to get it into textbooks. I believe, listen, I've taught it. I have never seen the term keto genic in a nutrition textbook. There's very, you know, listen, we talk about beta hydroxy butyrate, or acetol acetate in our biochemistry classes. We don't talk about them in our nutrition classes and they need that. They need to become part of our nutritional dogma that needs to become part of, but I think it'll take a decade for it to get there. There is no doubt in my mind that to live a full, healthy life, to take full advantage of both health span and lifespan, you have to autophagy, you have to, it has to be part of it. Intermittent, fasting or fasting is the shortest pathway to that. Spermidine helps. There's no doubt about it as you increase Burma nine autophagy increases as well. Don Moxley: But when you start talking about, you know let me think of an, an exercise analogy. I, you know, I can go in and I can go with, you know, listen, I watched the today show and inevitably every week they've got someone come on and do exercise and they show you how you can exercise with soup cans. Okay. darn close to masturbation, but not far from it. You know, if you want to do strength for longevity, you have to pick up some heavy stuff, really heavy stuff. This is, this is clear. Now whether you do it in a deadlift or a squat or something like that, I'm not going to argue, but you have to pick up heavy stuff. If you nutritionally, if you're going to, if you want longevity through nutritional sources, you've got to limit calorie intake. You've, you've practiced. Wade Lightheart: You got on you, consistent factor is calorie restriction. Don Moxley: Well, you have to eliminate sugars. Okay. You it's, you know, one of the biggest challenges that we have, we live in a society where we have, we have it's, I call it caloric toxic. You know, we have so much access to sugary drinks, which is the other end of the spectrum from from caloric restriction or autophagy, you know, and then when you go to, to intermittent fasting or fasting, ceremonial fasting, you know, there's a reason why it's included in every major religion in the world. You know, it's, it's a health benefit that comes with that. Wade Lightheart: What's old is new and old is leading the way. And I guess, so with your work, with sperma dime, what are, who is the people who are benefiting the most from sperm? Radine what kind of dosage do they require? Because you know, the devil's in the details and the devil's in the dosage. And so I guess is there a sliding scale based on age? Is there a responsiveness on age? Like can, maybe you can unpack some of that. Don Moxley: There's absolutely a responsiveness on age. So one of the things we do is that if you purchase sperming from our website, along the way, in our marketing process, you will get an invitation to have a phone call with either myself or one other. We have one other person that takes those calls in the company. I th I, we looked at that day to day, I think we've spoken with about 500 customers in the last 11, 10, 11 months, if you're 60 or 70 years old or over those people notice an effect to taking, spermatids almost within certainly within three weeks. Now remember what I said earlier, we see sperma nine levels start to drop with age. So, you know, and if you're in your thirties, if you're in your late thirties, I don't, I don't know that I'd recommend, well here, let me put it in this perspective. I think you look at longevity like you do it retirement. When you start investing in your 401k, it's certainly going to pay dividends on the long horizon, right. So if you have hi, sperma nine levels as a, as a 30 year old, and you continue to invest in it, it may take longer for you to feel it, to notice it. Again, when I go back to, when we talked to our CFO customers the older you are, Wade Lightheart: You'll be 95. You'll be nine. Yeah. I don't know if I'm feeling anything from this. Yes. Right, right. As you're dead lifting twice your body weight at the gym Don Moxley: And living the life that you want, you know, this is, this is, this is, what's so important. I think about, I think about, I think about London, Jevity like a hockey game. There's three periods. Right. And that's, I, my daughter played travel hockey. I'm just a nut. But you know, you spend the first period of your life in learning, you know, in school and growing up and you spend the second period of your life. What I call in service to others, work, raising family, things like that. But it's the third period of your life, you know, that's yours. Okay. It's, it's, you know, my wife, Jeff and I are getting ready to enter that. Say's that my daughter, who's now 23, she's finishing up her first year of grad school. She moved back in with us for grad school, which I could have never done with my parents. Don Moxley: But but you know, she'll move out of our home for sure in a year. And at that point in time, my wife and I moved in to our third period. And I, they want that, listen, I want that to be a rich time of my life. I tell the story that, you know, I've, I've coached Olympic medalists, I've coached national champions, I've coached men's and women's teams. I've worked with the women's volleyball team at Ohio state. We had one of the we're second in the country. We swept the big 10. We had great players. I love that experience. But without a doubt, my greatest coaching experience was when I got to coach my daughter's eighth grade field hockey team. That was awesome. Now, as I move into my third period, I want to coach my and kids' teams and my great grandkids teams. Don Moxley: And I want to be able to take my wife on trips of a lifetime. You know, if you look over my shoulder right now, you see the picture of my wife, that's on the shore up there in Michigan. The middle pictures of three of were up in lake Placid, New York at the Olympic training center. The little one were skiing in Colorado. My wife and I, I, you define yourself with the pictures on your wall. You know, no one takes a picture of a scale and hangs it on the wall, exercising to lose weight. The fitness industry failed with that goal failed big fat F. But when we start taking a look at fitness and longevity, these are the key elements. And again, it's about the pictures on the wall that you define yourself by. And that third, third is when I, you know, I'm just moving into mine. Don Moxley: So we're really focused on now with that being said, you have to think of longevity in half. So we're going to go from, from, we're going to go from hockey to soccer. You spend the first half of your life kind of in reproduction mode. And if you read David Sinclair's work in the sirtuin genes, moving from reproduction to longevity, it's interesting to see that we have, we actually have a genetic element that drives this. So at about 45 50, we see our bodies start to shift to longevity. You know, I listen again, when you start investing in the 401k, it's probably a good idea to start investing in longevity. Not just, not just supplements. And again, again, Spermidine life is a good supplement. I think it's important. But you invest in an exercise and good food and sleep and light and purpose Wade Lightheart: Right on, right on. So just circling back on that, I think that's great. So maybe early in their life, maybe people get you a little bit more attraction out of integrating, you know, time windows of eating or intermittent fasting or incorporating fasting. I know I incorporated fasting one day a week now it's almost 25 years ago. It was kind of ahead of the curve there. So it was, I was fortunate on that and I think it's a great practice. First, it gives you control. It allows a certain level of understanding is like, Hey, I don't need to eat all the time. Don Moxley: Right. When you get those enzymes, you get those fat utilization enzymes, cranked up. Wade Lightheart: Yeah. Which is great, but fasting isn't enough as we get longer because, you know, I always say, you know, one of the things in longevity work is they start adding all of these hormonal elements to longevity stuff. And I go, well, that's great, but that's like adding more trucks to the road. Right. what's in the factory for them, the haul they've got to have products and, and it would seem that Spermidine would be one of those ingredients that needs to be on the truck. If you're going for the long haul, how do you measure what we're seeing? What, how do you measure it in the body? Like where would you get this tested? And then could you, you know, follow, like, one of the things that we love doing is like, okay, well, I can test what my levels are. I can take the supplement and do I see an improvement over time to correlate with maybe how I feel? I like both sides of the, my intuitive feedback, what I'm experiencing, right. Also the data to support it, Don Moxley: Listen, and, and coming from me, you know, I'm a data guy that I wish I wish I had a blood marker. We don't have it yet. You know, we're working down deep in the cell. We have secondary markers that we see. And again, people who start taking sperma nine, who, who obviously are low. One of the first things they notice is a change in their hair, skin and nails. Because one of the, one of the byproducts of increase the Tava G is the upregulation of epithelial stem cells. So the cells that make new skin that turn into new nails, new hair, they get STEMI or with improved autophagy. And this is one of the first things people notice. One of the other early indicators that people notice is they'll see a change in their sleep data. Are you are you an aura guy or are you an HRV sleep measurement guy? Yeah, we're into Wade Lightheart: The, we're into the aura rings and we've got a bunch of them. We, we, we test all kinds of different ones. Don Moxley: So what you'll see a lot of times is a change in your deep sleep patterns with improved autophagy. One of the things that happened with me that I love, we hear this a lot from our customers is deep lucid dreaming which I love, I lie live feeling like I'm tripping in my sleep. Right. It's that's, that's one of the things we get. Now we have a third group. We have a third group that won't notice anything they'll use the product for 60 or 90 days they'll go off. And a lot of them within two weeks are like, okay, I didn't notice when I was on it, but I sure can tell when I'm off it. And we get them back right away and, and, you know, frankly, Wade, there's another, there's that fourth group, they just don't notice. And, and you know what, they've probably got good to toffee. They've probably got some things going well for them. So, you know, that's what we see. Wade Lightheart: Got it. So dosages what's, what's the suggested dosage. So the data, the data Don Moxley: Suggests that your daily supplementation should be around a milligram a day. And that's actually what we put into our product. Two tablets of sperma nine life gives you a milligram a day of, of spermicide. I would not be surprised to see us raise that level at some point in time. I'll tell you this. We have tested safety in Europe up to eight milligrams a day with safety issues. We are releasing a product this fall that will only be sold through physicians that is a six milligram per day product. So and, and so there's a lot of physicians that want a super dose their patients. So we've gone back and created a product for them. We have a lot of customers that are double dosing. They're going two times our recommended daily. And, and you know, what, when the data supports raising that number, we will raise that number and we'll put it in the bottle. We won't ask you to buy twice as much, but right now the science says a milligram a day. Wade Lightheart: Got it. That's great. And do you take that with food or empty stomach? Don Moxley: Take it with food? Our team in Austria seems to think that having a little bit of fat will help carry that molecule across the gut. So and we, you know, we have a lot of people, I don't know if you're a Bulletproof coffee guy. We have a lot of people that will break the capsules up into their Bulletproof coffee. I'd rather do it with a cold Bulletproof than a hot one. But but people do that way, but typically, and if you're going into a fast ticket with your last meal of the day before you Wade Lightheart: Found got it makes sense. We find, we found a lot of supplements are carried well on fats. Yeah. That's Don Moxley: Her listen, we've spent a long time, you know demonizing fats. And we've got to stop doing it. Wade Lightheart: Sorry about that. Don Moxley: Go ahead. Keep going on the fast, listen, fats are important. Quality fats are important, particularly omega-threes. You cannot ignore the value that come with dietary intake of omega threes. We have, again, you know, the way we have a super sh we have so much sugar available, available to us in our, in our food source. We have so many omega six is available to our foods are so we've got to get our mega three contents up because having that disbalance is, is problematic. Wade Lightheart: That's great. So for those who want to take advantage of this, they can go to spur benign life.com, Don Moxley: No dot U S U S spermidine. Life's not us. And if you use the code weighed 25, you can get a 25% discount. Okay. Wade Lightheart: Well, that's super generous. Thank you so much for that. Really appreciate that. Some of our listeners will take advantage of that. Where do you see the future of, you know, your science, your career? Where do you, where do you anticipate this is going as you enter into the third period, Don Moxley: Man, I've quit guessing. You know, I, again, if you would've told me, I'm sitting here talking to Wade, Lightheart on a podcast about this crazy molecule called, called sperma nine. If you'd have told me that five years ago, I said, well, you're obviously smoking crack. That's, that's not going to happen. But here we are. And you it's been again, back when I shifted from definition to mission, that was, that was, that was a mental decision to kind of pull back and quit trying to control. Let the universe puts you where you belong. I tell people, I try to throw up a radar dish and if you know, every opportunity that I see or come along, I vetted, I wanna understand it. I want to see it. You know, when I left, when I left high level human performance at Ohio state and went into cannabis, I thought, well, I'm done with that area. Don Moxley: You know, I, and it was, it was difficult. I mean, that was a really hard decision for me to make. But man, now I'm in this, you know, we're working with biohackers and I'm talking to customers and we're working with, with HRV and HR and, and, and literally I'm back right in the middle of it at a level that I could have never predicted. So you know what, I'm, I'm going to keep waking up every day and loving what I do. I love to teach, I love to learn. I spend about three hours a day, reading journal articles or reading books. I have a podcast feed. That's ridiculous. So I'm a huge supporter of zone two cardiovascular work. I can't do zone three, listening to podcasts. If I'm doing zone three out of five, I've got to have some music going. Don Moxley: Once I started doing real high intensity stuff, everything's off, you know, you're focusing on what you're doing, but if I'm doing zone three stuff, I usually do it with music. But my zone two stuff, you know, I've given myself permission. There's a lot of value to exercising in zone two. It's mitochondria a lot of mitochondrial development. There's just a lot of good things that come from that. I wouldn't recommend it necessarily for a college athlete. You need to shift your zones up a little bit, but once you finish up your college athletics, all their parents in the rest of the world, you know what zone two is a good place to be. And I do that with podcasts and books on tape. And you know, now that I'm back traveling again I just absolutely devour books on audible book. Wade Lightheart: Love it. Can you share with everybody where they can reach you follow? You have Instagram, Facebook, social media, all. Yeah. Don Moxley: So you can find me, listen, I've gotten Don Moxley locked down at most of us. I'm on Instagram at Don Moxley. I'm on Facebook, Don Moxley. I'm on LinkedIn at Don Moxley. You can find me at all those Twitter, Don Moxley. My Twitter feed is typically where I'm pushing science information, longevity, information, things like that. I don't, I don't quite, I don't have a strong Instagram game yet. You know, I'm just not into taking pictures and, and doing that. Wade Lightheart: I, I get it. I have a team that handles that for me, full barbell mentality is like, I want to, I want to get into it. I want to take it. There's some Don Moxley: People that are so good at it. And I'm just like, I just, I, I, I'm just not there. So Twitter is where I really push information now. Spermidinelife has Instagram Spermidinelife U S we're, we're on Facebook as well. Spermidinelife.Us so you can follow us there and we're doing a better job of bringing our social media game up. And you're going to see us soon in Twitter and LinkedIn, Wade Lightheart: Don, this has been very informative wish you and your team, and spernin life, the best of success. And we'll see what probably the next wake up event out here in orange county or in Los Angeles as we've launched it. Yeah, Don Moxley: If not, if not before we're BA listen, this, this whole longevity biohacking, thing's big in Southern California, a lot bigger than Ohio. So I'm spending a lot of time on airplanes going back. Wade Lightheart: Sweet. We'll look forward to seeing you soon. And for all our listeners, I hope you enjoyed this episode and take a chance and try sperm. And I might be just the thing you're looking forward to live long lives. Strong. We're all about that at BiOptimizers I'm Wade T. Lightheart from BiOptimizers and the Awesome Health Podcast. Hope you enjoyed this and we'll see you on the next episode. Take care.